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OpenTrials
Completed

NCT Number: NCT00515905

One-lung Ventilation: Expression of Pulmonary Inflammatory Mediators

One-lung ventilation; organ protection; volatile anesthetics

One-lung ventilation has become a common procedure for thoracoscopic surgery. Two hypothesis will be tested in this study:

1. Are inflammatory mediators increased in the re-ventilated lung after short-period pulmonary collapse? 2. Does Sevoflurane influence the production of inflammatory mediators in the re-inflated lung? Therefore, this study will elucidate the potential protective effect of a volatile anaesthetic (sevoflurane) on the production of inflammatory mediators by the respiratory compartment of the lung, i.e. the alveolar epithelium.

* Trial with immunomodulatory product / biological

Completed

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Key information

Conditions

Thoracic Surgery With One-lung Ventilation

Age range

18 year–75 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

University Hospital of Zurich

Zurich, Switzerland

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Thoracic surgery (thoracotomy, thoracoscopy) with one-lung ventilation

Exclusion criteria

  • Immunosuppressive therapy
  • Ongoing inflammatory processes

Treatment and study plan

Sevoflurane/propofol

Drug

Sevoflurane/propofol

Primary outcomes

  1. One-lung ventilation measurement in the re-ventilated lung after short-period pulmonary collapse

    Time frame: Sep 07

Sponsors and collaborators

Lead sponsor

University of Zurich

Other

Registry information

Official study title

Lung: One-lung Ventilation: Expression of Pulmonary Inflammatory Mediators After Deflation and Re-expansion of the Lung During Thoracic Surgery

Important dates

Study start
2004
Primary completion
2007
Study completion
2007
First posted
Aug 14, 2007
Registry last updated
Sep 15, 2010

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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