Once-daily Therapy for Streptococcal Pharyngitis

In some studies once daily amoxicillin therapy might be treatment of choice for Group A β-hemolytic Streptococcus pharyngitis in comparison with three to four times daily treatment with oral penicillin V.

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Key information

Conditions

Streptococcal Sore Throat Infections Otorhinolaryngologic Diseases Pharyngeal Diseases Pharyngitis Respiratory Tract Diseases Respiratory Tract Infections Stomatognathic Diseases

Age range

6 year–15 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 1

Primary location

Islamic Azad University

Mashhad, Khorasan, 91796, Iran

Who can participate

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Age of 6 to 15 years old.
The criteria in clinical examination including objective signs (fever, Erythema or exudate of tonsils, enlarged lymph nodes) and subjective sign(sore throat). Neck tenderness, abdominal pain and pharynx petechia were also considered.
No antibiotic was used during the week before.
-Performing throat culture before the initiation of drug administration
Positive throat culture indication GABHS
No previous history of allergy to penicillin .

Exclusion criteria

Age of below 6 years old or above 15 years old.
No signs of pharyngitis in the clinical examination
Antibiotic use during the week before.
Throat culture was not performed before the initiation of drug administration.
Negative throat culture or the culture indicates a microorganism other than GABHS.
History of allergy to penicillin
Not using drugs or not following the treatment in the field of having the second culture performed.

Treatment and study plan

Amoxicillin

Drug

Intramuscular Benzathin Penicillin G

Drug

It is mentioned underlined in page 10 in research. (Once the throat swab was taken and cultured on plate at the place where the child was examined, hygiene teacher was trained about how to prepare the oral amoxicillin suspension and how to give it to the child. 750 milligrams of amoxicillin was thereafter given to the patient and in order not to infect other school children, the patient was sent home. The following morning, the patient would come to school and was given the second dose of amoxicillin by the hygiene teacher. All oral drugs were bought from a creditable company. In the injection group, 600000 units of penicillin was administered to children who weigh less than 27 kilograms and 1200000 units of penicillin was administered to children who weigh more. After 48 hours, patients were examined again when the result of first culture was ready)

Sponsors and collaborators

Lead sponsor

Azad University of Medical Sciences

Other

Registry information

Important dates

Study start: 2004
Study completion: 2006
First posted: Mar 8, 2011
Registry last updated: Mar 8, 2011

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed