Pamela Youde Nethersole Eastern Hospital
Hong Kong
Location status: Recruiting
Location contact
Kai-Chuen, Fergus Wong
CONTACT
Recruiting
NCT Number: NCT05364125
Olfactory Training on Smell Dysfunction Patients in HK
* Causes of olfactory dysfunction can be classified into conductive and sensorineural causes. * Conductive causes are mainly due to structural nasal problem, which can be treated by nasal surgery * Sensorineural causes included post-infection, post-head injury, post Head and Neck irradiation and other central nervous system diseases. * Olfactory Training is well established treatment for sensorineural olfactory dysfunction in foreign countries. * Olfactory Training by neurological chemosensory stimulation using aromatic substances delivered via electronic portable aromatic rehabilitation (EPAR) diffuser was proved to be effective treatment in COVID-19 related olfactory dysfunction in recent Hong Kong study. * However, there is a lack of local study on the effect of Olfactory Training in other non-COVID-19 sensorineural causes of olfactory dysfunction in Hong Kong population.
Recruiting
Interested in participating?
Request InfoKey information
Conditions
Age range
18 year–70 year
Sex eligibility
All sexes
Study type
Interventional
Phase
Not applicable
Primary location
About this study
Design Prospective double-blinded randomized control trial.
Study Period 1/7/2022 - 30/6/2024 for case recruitment.
Suitable patient will be recruited. Informed consent will be signed. Objective smell assessment will be done using the University of Pennsylvania Smell Identification Test (UPSIT) and Butanol Threshold Test (BTT). Subjective quality of life score will be obtained by Sino-Nasal Outcome Test (SNOT-22). Subjective smell and taste assessment will be assessed by Visual Analogue Scale (VAS). Patient will be randomized into treatment group and control group using computer generated list by an independent nursing staff. Doctors and the patients will be blinded during the study.
Who can participate
Healthy volunteers accepted: No
Only the study team can determine whether someone qualifies for participation.
Inclusion criteria
- Olfactory dysfunction > 6 months and < 5 years
Exclusion criteria
- History of significant head injury (fracture, ICH)
- History of brain surgery
- History of nasal surgery
- Active nasal disease
- Active neurological disease
- Poor premorbid status/ non-communicable patients
- Mentally incompetent patients
- <18 years' old
- Pregnancy
- Hypersensitivity to the aromatic substance.
Treatment and study plan
Olfactory Training
OtherFour aromatic substances will be used (Citrus limon, Eucalyptus radiata, Pelargonium graveolens, Juniperus virginiana)
Control
OtherNormal Saline will be used
Primary outcomes
-
Olfactory threshold changes after olfactory training after 3 months
Time frame: 3 months after starting smell training
Parameter:
Olfactory threshold using Butanol Threshold Test (BTT)
-
Olfactory identification score changes after olfactory training after 3 months
Time frame: 3 months after starting smell training
Parameter:
Olfactory identification using Smell Identification Test (UPSIT)
-
Quality of life changes after olfactory training after 3 months
Time frame: 3 months after starting smell training
Parameter:
Subjective quality of life score using Sino-Nasal Outcome Test (SNOT-22)
-
Taste and smell changes after olfactory training after 3 months
Time frame: 3 months after starting smell training
Parameter:
Subjective smell and taste assessment using Visual Analogue Scale (VAS)
Study contacts
Contact information is provided by the study sponsor or research team.
Ka Chung Kwan, FRCSEd(ORL)
CONTACT
Kai Chuen Fergus Wong, FRCSEd(ORL)
CONTACT
Sponsors and collaborators
Lead sponsor
Pamela Youde Nethersole Eastern Hospital
Other
Registry information
Official study title
Effect of Olfactory Training on Olfactory Dysfunction Patients in Hong Kong Population
Important dates
- Study start
- 2022
- Primary completion
- 2027
- Study completion
- 2027
- First posted
- May 6, 2022
- Registry last updated
- Jun 3, 2025
OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.
View the official ClinicalTrials.gov record (opens in a new tab)This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.
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