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OpenTrials
Completed

NCT Number: NCT05996237

Older Adults' Readiness to Stop Prescribed Medications

Polypharmacy, regular use of 5+ prescribed medications, is common among older adults and potentially harmful. Patients differ in their concern about medications, comfort in raising questions about them, and trust and confidence in physician judgment. This pilot observational research will determine older adults' readiness to "deprescribe," that is, stop prescribed medications under physician guidance.

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Key information

Age range

65 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

University of Pittsburgh

Pittsburgh, Pennsylvania, 15261, United States

About this study

The purpose of this research is to assess readiness to deprescribe, that is, to determine how willing patients are to stop prescriptions that may no longer be necessary or may no longer have a favorable benefit-risk ratio. This readiness depends on many factors, including a patient's trust in a health care provider, how proactive patients are in seeking care, and patients' comfort in changing longstanding medical regimens.

The proposed two-wave survey research will use validated instruments and recruit from an older adult research registry to determine (i) readiness to deprescribe at baseline, (ii) correlates of such readiness, and (iii) effects of intercurrent illness and changing health on readiness to deprescribe at 6 months.

Specific aims:

  • Determine readiness to deprescribe among a sample of patients with 5+ prescriptions using validated scales.
  • Determine correlates of readiness to deprescribe. Patients differing in age, gender, race, education, and comorbidity may differ in willingness to stop prescribed medications.
  • Determine the effect of intercurrent illness on readiness to deprescribe. Over 6 months, we anticipate some patients will have a new onset of illness or hospitalization, or increasing levels of disability. We would like to determine if these changes in medical status affect readiness to deprescribe.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • 65 years or older
  • Medical visit within past 6 months
  • Self-report of at least 5 regular medications for at least 4 weeks

Exclusion criteria

  • Diagnosis of dementia or score <=4 on Memory Impairment Screen
  • Hospitalization in prior 30 days with change in medications

Treatment and study plan

Primary outcomes

  1. Patient Motivation to Deprescribe

    Time frame: Change over 6 months

    Self-report measure (Linsky 2020): range 1-5; high scores = greater readiness to deprescribe; mean (SD) in VA sample 2.99 (0.80)

Secondary outcomes

  1. Self-reported stopping/changing prescription medication

    Time frame: 6 months

    Self-report of stopping, tapering, or altering use of any prescription, with or without physician discussion

Sponsors and collaborators

Lead sponsor

University of Pittsburgh

Other

Registry information

Official study title

Older Adults' Readiness to Stop Prescribed Medications with Guidance from Health Care Professionals

Important dates

Study start
2023
Primary completion
2024
Study completion
2024
First posted
Aug 18, 2023
Registry last updated
Jan 9, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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