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OpenTrials
Completed

NCT Number: NCT00103571

Olanzapine Versus Aripiprazole in the Treatment of Acutely Ill Patients With Schizophrenia

The purposes of this study are to assess similarities and differences in the efficacy (how well the drug works), safety, and side effects of olanzapine and aripiprazole in patients with schizophrenia, schizoaffective disorder, or schizophreniform disorder.

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Key information

Conditions

Schizophrenia Mental Disorders Schizophrenia Spectrum and Other Psychotic Disorders

Age range

18 year–55 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 4

Primary location

For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician. test, Rio Piedras, Puerto Rico

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Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients must have schizophrenia, schizoaffective disorder, or schizophreniform disorder
  • Patients must be agitated
  • Patients must display psychotic symptoms
  • Patients must be inpatients who are expected to stay in the hospital for at least 5 days
  • Patients must be 18 to 55 years of age

Exclusion criteria

  • Patients may not be hospitalized for greater than 72 hours prior to study start
  • Patients may not have received more than one dose of olanzapine or aripiprazole within 72 hours prior to study start
  • Patients may not be actively suicidal
  • Patients may not be diagnosed with substance-induced psychosis or substance dependence
  • Patients may not have acute, serious, or unstable medical conditions

Treatment and study plan

Olanzapine

Drug

Aripiprazole

Drug

Primary outcomes

  1. The primary objective of this study is to test the hypothesis that olanzapine is superior to aripiprazole in the reduction of symptoms of agitation in acutely ill patients with schizophrenia, as measured by mean change in the

  2. Positive and Negative Syndrome Scale Excited Component (PANSS-EC) over 5 days of treatment (4 continuous 24 hr treatment exposures). The null hypothesis of the study is that there is no difference between olanzapine and

  3. aripiprazole in reducing agitation.

Secondary outcomes

  1. The reduction in positive symptoms as measured by the Brief Psychiatric Rating Scale Positive subscale (PBRS Positive);

  2. The reduction of symptoms of agitation as measured by Overt Agitation Severity Scale (OASS);

  3. The proportion of patients responding to treatment and the time to response based on varying levels in the percent reduction of

  4. the PANSS_EC from baseline;

  5. The reduction in overall severity of psychiatric illness as measured by the Clinical Global Impression-Severity Scale (CGI-S);

  6. The intensity of nursing intervention (e.g. seclusion, restraint, special nursing watch), as measured by the Global Assessment

  7. of Nursing Intervention

  8. The proportion of patients using pm lorazepam and the time-course of usage.

  9. The proportion of patients discontinuing from the study due to lack of efficacy or due to adverse events related to worsening

  10. of psychiatric illness.

  11. Patient satisfaction with their medication, as measured by Drug Attitude Inventory (DA1-10).

  12. A sensitivity analysis will be performed on two randomly chosen subsamples of the overall patient population by analyzing the

  13. primary objective respectively.

  14. Additional secondary objectives of the study are to compare the safety of olanzapine versus aripiprazole over the course of 5

  15. days in the treatment of acutely ill patients with schizophrenia as assessed by:

  16. Relative degree of sedation as measured by the Agitation Calmness Evalution Scale (ACES);

  17. Review of spontaneous (unsolicited) treatment emergent adverse events;

  18. Development of extrapyramidal symptoms as assessed by daily Modified Simpson-Angus and Barnes Akathisia scale scores.

Sponsors and collaborators

Lead sponsor

Eli Lilly and Company

Industry

Registry information

Important dates

Study start
2004
Study completion
2006
First posted
Feb 11, 2005
Registry last updated
Nov 6, 2007

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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