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Completed

NCT Number: NCT00182507

Olanzapine in the Treatment of Hair Pulling (Trichotillomania)

Trichotillomania (TTM) or hair-pulling has been considered as part of the obsessive compulsive disorder (OCD) spectrum, although treatment with OCD medications has largely been unsuccessful. Tics/Tourrettes' Syndrome (TS) is a disorder, which appears to be related to TTM, but is treated with a different class of medications than used in OCD, namely antipsychotics such as olanzapine. This is a study of the safety and efficacy of olanzapine in the treatment of hair pulling.

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Key information

Conditions

Trichotillomania Anxiety Disorders Disruptive, Impulse Control, and Conduct Disorders Mental Disorders Obsessive-Compulsive Disorder

Age range

18 year–65 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 4

Primary location

Hamilton Health Sciences, McMaster University Medical Centre

Hamilton, Ontario, L8N 3Z5, Canada

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • primary DSM-IV trichotillomania; CGI-Severity ≥ 4

Exclusion criteria

  • Any other Axis I primary diagnosis; CGI-S < 4; current comorbid: OCD, MDD, alcohol or substance abuse; lifetime hx of: schizophrenia, bipolar affective disorder or dementia; current pregnancy/lactation; current suicidality or homicidality; major medical problems or clinically unstable medical disease; hx of: seizures, stroke or head trauma; prior use of neuroleptics

Treatment and study plan

Olanzapine

Drug

Primary outcomes

  1. Clinical Global Impression (CGI)-Improvement Scale ≤ 2

Secondary outcomes

  1. CGI-Severity Scale, Mean change from baseline in: Yale-Brown Obsessive Compulsive Scale for TTM, the Massachusetts General Hospital Hair Pulling Scale

Sponsors and collaborators

Lead sponsor

Hamilton Health Sciences Corporation

Other

Collaborators

  • Eli Lilly and Company

Registry information

Official study title

A 12-Week, Double-Blind Trial of Olanzapine and Placebo in the Treatment of Trichotillomania

Important dates

Study start
2000
Study completion
2006
First posted
Sep 16, 2005
Registry last updated
Sep 11, 2006

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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