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OpenTrials
Completed

NCT Number: NCT02298881

Ocular Surface Microbiome

The purpose of this study is to collect samples from the surface of eyelids to try to grow and identify bacteria or fungus that might be present, and to try to understand why people have dry eye symptoms.

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Key information

Conditions

Dry Eye Syndromes Eye Diseases Lacrimal Apparatus Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

UW Medicine Eye Institute

Seattle, Washington, 98104, United States

About this study

"Dry eye" is a very common eye condition, which may or may not be caused by specific microorganisms that live on the surface of the eye. In this study, a combination of tissue culture and molecular biology techniques will be used to identify every microbe (bacteria, fungus, or virus) on the surface of eyes of people with dry eye syndrome, as well as a 'control' group of people who don't have dry eye disease.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Subjects with ocular surface discomfort with an Ocular Surface Disease Index score of greater than 60
  • Subjects with and Ocular Surface disease Index score less than 30
  • Males and females age 18 or older

Exclusion criteria

  • Contact lens wear
  • Use of oral or topical antibiotics in past 6 months
  • Use of prescription eye medication in past 6 months
  • Penetrating ocular or keratoplasty surgery in last 12 months
  • Children under the age of 18

Treatment and study plan

Primary outcomes

  1. To catalog the bacteria and other micro-organisms that are naturally found on the eye surface.

    Time frame: 6 months

Sponsors and collaborators

Lead sponsor

University of Washington

Other

Collaborators

  • National Eye Institute (NEI)
  • National Institutes of Health (NIH)

Registry information

Official study title

Diversity and Dynamic Stability of the Ocular Surface Microbiome

Important dates

Study start
2013
Primary completion
2021
Study completion
2021
First posted
Nov 24, 2014
Registry last updated
May 7, 2021

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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