Centre Hospitalier National d'Ophtalmologie des Quinze-Vingts
Paris, 75012, France
Location status: Recruiting
NCT Number: NCT06976034
Understanding the pathogenesis of eye diseases has benefited greatly from recent advances in ophthalmic imaging. However, current clinical imaging systems, such as optical coherence tomography (OCT), are limited in terms of resolution, acquisition speed or access to certain eye functions. Our team has participated in the development of a new generation of imaging technology known as optical transmission tomography (OTT), which enables imaging of the anterior parts of the eye with high cellular resolution, a wide field of view and reduced examination delay.
Interested in participating?
Request Info18 year–80 year
All sexes
Interventional
Not applicable
Paris, 75012, France
Location status: Recruiting
For healthy subjects: an imaging examination using each system (OTT + OCT + specular microscopy) will be carried out twice, at an interval of two (2) years (inclusion visit + visit at 24 months). Several imaging images will be taken by two different operators during these sessions.
For patients: an imaging examination using each system (OTT + OCT + specular microscopy) will be carried out by two different operators, and several imaging images will be taken. These examinations will be carried out at the inclusion visit and at the following visits according to the disease assessment schedule, lasting up to a maximum of 4 years.
Healthy volunteers accepted: Yes
Only the study team can determine whether someone qualifies for participation.
Inclusion criteria
For Patients:
For Healthy volunteers:
Exclusion criteria
For all participants:
Multiple imaging sessions added by research using the systems described (OTT) will be carried out by two different operators at different positions during these sessions.
Multiple imaging sessions (OCT) already used in standard of care will be performed by two different operators at different positions during these sessions.
Multiple imaging sessions (SM) already used in standard of care will be performed by two different operators at different positions during these sessions.
Time frame: between 1 day and 4 years
Quality assessed by two blinded experts.
This is an evaluation of image quality in terms of operation according to the following scheme.
Quality assessment:
If no, tick yes, below and fill in the cause:
Insufficient quality: ☒ yes ☐ no
Cause:
Time frame: between 1 day and 4 years
Assessment of endothelial cell density.
Time frame: between 1 day and 4 years
corneal and lens structures:measure density in other cell types
Contact information is provided by the study sponsor or research team.
Centre Hospitalier National d'Ophtalmologie des Quinze-Vingts
Other
Acronym: CERES-OTT
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