Ocular Blood Flow Imaging for Glaucoma Assessment

The investigators will capture images of the participant's retina using the XyCAM RI or XyCAM FC ("test data") and by color fundus photography, optical coherence tomography (OCT), and standard automated perimetry (SAP) - the "standard clinical data". The investigators will perform five tests. The first two tests will be conducted using the XyCAM RI or XyCAM FC to obtain "test data". The final two tests will be conducted using routine clinical instruments to obtain "standard clinical data". The investigators will administer eye drops (Tropicamide) to dilate the participant's pupils prior to the first test. Tropicamide is a chemical that causes pupil dilation and is commonly used by doctors to examine the participant's eyes. The entire set of test data sessions should last less than eighty (80) minutes with an additional 60 minutes for carrying out the necessary procedures and imaging using the standard clinical data.

Inclusion criteria

• Age 18 and older with binocular vision
• Able to provide informed consent
• Patient is a healthy control OR is recommended for glaucoma assessment OR diagnosed with moderate to severe glaucoma in at least one eye as determined by Hodapp Anderson Criteria

Exclusion criteria

• The subject has significant media opacity (e.g., a visually significant cataract or significant corneal scar)
• The subject has previous ocular surgery other than uncomplicated cataract extraction, laser trabeculoplasty (ALT or SLT), or YAG capsulotomy
• The subject has prior ocular disease other than glaucoma
• The subject has anatomically narrow angles or a prior adverse reaction to administration of Tropicamide or fluorescein dye
• The subject has more than 15 diopters of refractive error
• The subject is a female who is pregnant or nursing
• The subject has diabetes mellitus