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OpenTrials
Completed

NCT Number: NCT04689789

OCTA and Retinal Angiomatous Proliferation

To investigate, using optical coherence tomography angiography, the retinal vascular features in patients affected by RAP.

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Key information

Conditions

Age Related Macular Degeneration Eye Diseases Macular Degeneration Retinal Degeneration Retinal Diseases

Age range

65 year–80 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Federico II University

Naples, Napoli, 80131, Italy

About this study

Retinal vascular anomalous complex represents a distinct form of neovascularization in patients with age-related macular degeneration.

The study investigated the changes in retinal vascular network using optical coherence tomography angiography, a novel and non invasive diagnostic technique that allows to better understand the pathophysiologic mechanism of this neovascularization.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • age older than 65 years
  • diagnosis of retinal angiomatous proliferation and reticular pseudodrusen
  • absence of previous ocular surgery, congenital eye disease, high myopia (>6 dioptres), actual or previous diagnosis of glaucoma, optic disc anomaly, macular or vitreoretinal diseases.
  • absence of significant lens opacities, low-quality OCT-A images.

Exclusion criteria

  • age older than 80 years
  • absence of diagnosis of retinal angiomatous proliferation and reticular pseudodrusen
  • presence of previous ocular surgery, congenital eye disease, high myopia (>6 dioptres), actual or previous diagnosis of glaucoma, optic disc anomaly, macular or vitreoretinal diseases.
  • presence of significant lens opacities, low-quality OCT-A images.

Treatment and study plan

Optical Coherence tomography angiography

Diagnostic Test

optical coherence tomography aniography is a non-invasive, fast, diagnostic imaging technique that evaluates the retinal vascular network

Primary outcomes

  1. The measurements of retinal vascular network in patients with age-related macular degeneration, using optical coherence tomography angiography, compared to controls

    Time frame: 15 months

    The parameters analyzed by optical coherence tomography angiography were: vessel density of superficial capillary plexus and deep capillary plexus

Sponsors and collaborators

Lead sponsor

Federico II University

Other

Registry information

Official study title

The Role of Quantitative Deep Capillary Plexus in the Pathogenesis of Retinal Angiomatous Proliferation: an Optical Coherence Tomography Angiography Study.

Important dates

Study start
2019
Primary completion
2020
Study completion
2020
First posted
Dec 30, 2020
Registry last updated
Dec 30, 2020

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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