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NCT Number: NCT07298746

Oct Angiography Changes After Local Anesthesia in Cataract Surgery

Assessement of retinal microvasculature detected by OCT-angio after peribulbar &retrobulbar anesthesia in cases undergoing cataract surgery .

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Key information

Age range

40 year–80 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

About this study

prospective , interventional,comparative , clinical study utilizing a pre-post, within-subject design ,which will be conducted in the Department of Ophthalmology ,Sohag University Hospital ,Egypt.

Optical coherence tomography angiography (OCTA) will be performed before and after the administration of retrobulbar and peribulbar local anesthesia in the same cohort of patients, in order to evaluate the immediate effects of the anesthetic intervention on retinal microvascular parameters.the study will be conducted on patients aged 40-80 years with elective cataract surgery requiring regional block.the study will be divided into two main groups :

  • Group with peribulbar anesthesia injection.
  • Group with retrobulbar anesthesia injection.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • patients aged 40-80 years.
  • patients with elective cataract surgery requiring regional block.

Exclusion criteria

  • 1.Allergy to study drugs. 2. Media opacities affecting OCT imaging (corneal pathologies, dense cataracts, vitreous.

opacities, etc). 3. Patients with any other retinal vascular diseases (retinal vein occlusion, central serous chorioretinopathy, age-related macular degeneration, etc).

  • Patients who have had previous intravitreal injections or Laser treatment. 5. Patients who underwent previous vitreoretinal surgeries. 6. Patients with uncontrolled glaucoma or ocular inflammations (eg: vitritis). 7.Patients with diabetes mellitus or hypertension.

Treatment and study plan

Local Anesthesia (peribular injection of both lidocaine 2 % and hyaluronidase 150IU\ML)

Drug

peribular injection of both lidocaine 2 % and hyaluronidase 150IU\\ML

Local Anesthesia (peribulbar anesthesia injection of mepivacaine 2% and hyaluronidase 150IU\ML)

Drug

peribulbar anesthesia injection of mepivacaine 2% and hyaluronidase 150IU\\ML

Local Anesthesia (retrobulbar anesthesia injection of lidocaine 2 % and hyaluronidase 150IU\ML)

Drug

retrobulbar anesthesia injection of lidocaine 2 % and hyaluronidase 150IU\\ML

local Anesthesia (retrobulbar anesthesia injection of mepivacaine 2% and hyaluronidase 150IU\ML)

Drug

retrobulbar anesthesia injection of mepivacaine 2% and hyaluronidase 150IU\\ML

Primary outcomes

  1. Macular superficial capillary plexus (SCP) and deep capillary plexus (DCP

    Time frame: ntervention & data collection :4-6 monthes

    to detect degree of changes in vessel density at superficial and deep macular plexuses before and after injection of each group of anesthesia

Study contacts

Contact information is provided by the study sponsor or research team.

Amira aldesoky abdelazeem ahmed, resident

CONTACT

[email protected]

01055330581

Mohamed Anber Abdellatif, professor

CONTACT

01009801966

Sponsors and collaborators

Lead sponsor

Sohag University

Other

Registry information

Official study title

OCT Angiography Changes of Retinal Microvasculature After Local Anesthesia in Cases Undergoing Cataract Surgery

Important dates

Study start
2025
Primary completion
2026
Study completion
2027
First posted
Dec 23, 2025
Registry last updated
Dec 23, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.