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NCT Number: NCT04389437

OCT-Angiography and Adaptive Optics in Patients With Memory Impairment

Studies suggest an association between retinal abnormalities and NCD (Neuro Cognitive Disorders) whether they are linked to proven or prodromal Alzheimer's disease (aMCI : amnestic mild cognitive impairment), or to other neurodegenerative diseases such as frontotemporal dementia or Lewy body diseases.

These retinal anomalies objectified by OCT-A (Optical coherence tomography angiography) and adaptive optics (AO) appear different depending on the pathologies and could therefore serve as markers in vivo of the pathophysiological processes underlying NCD.

No study to date has studied the retina and its vessels in NCD using adaptive optics. In this pilot study, we are proposing a combination of two new ophthalmological imaging techniques (OCT-A and AO), which allow rapid in vivo analysis in a completely non-invasive way of the morphology of small vessels as well as architecture of the retina to better specify the retinal anomalies associated with NCD. We will compare the parameters in OCT-A and AO between patients with NCD and controls without NCD (with memory complaint or without) and will seek to determine if there are different profiles according to the causes of NCD.

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Key information

Conditions

Amnesia Alzheimer Disease Basal Ganglia Diseases Brain Diseases Central Nervous System Diseases Dementia Lewy Body Disease Memory Disorders Mental Disorders Movement Disorders Nervous System Diseases Neurobehavioral Manifestations Neurocognitive Disorders Neurodegenerative Diseases Neurologic Manifestations Parkinsonian Disorders Parkinsons Disease With Dementia Pathological Conditions, Signs and Symptoms Signs and Symptoms Synucleinopathies Tauopathies

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patient presenting in memory consultation for memory complaint or person accompanying a patient in memory consultation for memory complaint

Exclusion criteria

  • pregnant or lactating women
  • history of known non-degenerative neurological pathology (tumor, stroke territorial, in particular multiple sclerosis)
  • history of retinal pathology
  • ametropia greater in absolute value than 3 diopters on the sphere, or/and 1.5 diopters on the cylinder.
  • history of taking ethambutol for more than 2 months
  • history of takingsynthetic antimalarial for more than 2 years
  • Mini Mental State Score (MMS) and / or Montreal Cognitive Assessment (MoCA) <10 for patients and 26 for accompanying persons
  • MRI contraindication (for patients only)

Treatment and study plan

Ophthalmological exam

Procedure

OCT-A and AO

Blood Pressure Measurement

Procedure

Blood pressure measurement before the ophthalmological exam

Primary outcomes

  1. Wall to lumen ratio (WLR)

    Time frame: Baseline (Inclusion)

    Measured in adaptive optics, compared between patients case with NCD and patient controls without NDC found

Study contacts

Contact information is provided by the study sponsor or research team.

Amélie YACHITZ, MD

CONTACT

[email protected]

(0)148036454 ext. +33

Antoine MOULIGNIER, MD

CONTACT

[email protected]

Sponsors and collaborators

Lead sponsor

Fondation Ophtalmologique Adolphe de Rothschild

Network

Registry information

Acronym: OCTAVO

Important dates

Study start
2020
Primary completion
2026
Study completion
2026
First posted
May 15, 2020
Registry last updated
Sep 29, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

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This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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