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NCT Number: NCT02674230

OCEAN Registry: Obesity and Clock for Elegant Aging Registry

This study aims to study the relationships between obesity, circadian rhythm, and aging. The investigators set up a prospective cohort registry for morbid obesity, obesity, and normal subjects with annual follow-up. The cohort aims to investigate the pathophysiological, molecular, genetic, and cellular aspects of the relationships between obesity, circadian deregulation, and impacts on aging. Clinical data, questionnaires, biological material, and molecular signatures will be collected and investigated.

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Key information

Conditions

Obesity Aging Body Weight Cardiovascular Disease Cardiovascular Diseases Chronobiology Disorders Circadian Dysregulation Nervous System Diseases Nutrition Disorders Nutritional and Metabolic Diseases Overnutrition Overweight Pathological Conditions, Signs and Symptoms Signs and Symptoms

Age range

20 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Chang Gung Memorial Hospital

Taoyuan, 333, Taiwan

Location status: Recruiting

Location contact

Chao-Yung Wang, MD

CONTACT

[email protected]

886-3-3281200 ext. 8750

Chao-Yung Wang, MD

PRINCIPAL_INVESTIGATOR

Ming-Shien Wen, MD

PRINCIPAL_INVESTIGATOR

Ta-Sen Yeh, MD

PRINCIPAL_INVESTIGATOR

About this study

The objective of this observational study is the follow-up of 2000 adult obesity (BMI ≥ 35 and 24-35 kg/m2) and non-obese subjects with annual follow-up for 10 years. Clinical data, biochemistry, and biological samples (serum, DNA, RNA, white blood cells) will be collected and stored. Adipose tissues will be collected if participants received liposuction, plastic surgery, bariatric surgery, dermatological procedure, intra-abdominal operation, and cardiovascular surgery. Questionnaires will be obtained with special nurse including sleep quality, chronotypes, and circadian activities. During follow up period, major adverse cardiovascular events will be monitored.

The investigators anticipate that the results generated from the study will provide valuable data to a better understanding of the relationships between obesity, circadian rhythm, and aging.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age ≥ 20 years old
  • Body mass index ≥ 24 kg/m2
  • For normal subjects, Body mass index < 24 kg/m2

Exclusion criteria

  • No inform consent
  • Use of steroid medications
  • Severe systemic diseases or organ failure with estimated life expectancy of 6 months or less

Treatment and study plan

Primary outcomes

  1. Body weight

    Time frame: 10 years

Secondary outcomes

  1. Major Cardiovascular Adverse Events

    Time frame: 3, 6, 12, and 18 months. 2, 5, and 10 years

  2. Sleep quality as assessed by Pittsburgh Sleep Quality Index (PSQI) questionnaire

    Time frame: 3, 6, 12, and 18 months. 2, 5, and 10 years

  3. Personal chronotype (biological clock) as assessed by Munich Chronotype Questionnaire

    Time frame: 3, 6, 12, and 18 months. 2, 5, and 10 years

Study contacts

Contact information is provided by the study sponsor or research team.

Chao-Yung Wang, MD

CONTACT

[email protected]

886-3-3281200 ext. 8750

Sponsors and collaborators

Lead sponsor

Chang Gung Memorial Hospital

Other

Registry information

Official study title

OCEAN Registry: Obesity and Clock for Elegant Aging Registry 肥胖控制及生理時鐘之研究計畫

Acronym: OCEAN

Important dates

Study start
2011
Primary completion
2035
Study completion
2035
First posted
Feb 4, 2016
Registry last updated
Jun 23, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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