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Completed

NCT Number: NCT04611984

OC and ICTP in Gingival Crevicular Fluid During Piezocision Accelerated Orthodontic Treatment

The aim of this study was to evaluate the tooth movement with and without piezocision with regard to the levels of osteocalcin and cross-linked C-terminal telopeptides of type I collagen in the gingival crevicular fluid.

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Key information

Conditions

Tooth Movement

Age range

13 year–20 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Marmara University Faculty of Dentistry

Istanbul, 34854, Turkey (Türkiye)

About this study

15 systemically healthy subjects requiring extraction of the maxillary 1. premolars with distalization of the maxillary canines were enrolled to the study. Piezocisions were performed on the distal and mesial sides of the right maxillary canines while the left maxillary canines served as controls. Canine distalization was performed via closed-coil springs applying 150 g of force per side by using miniscrews as anchorage. Gingival crevicular fluid samples were collected from both mesial and distal sides of right and left maxillary canines at 0, 1, 7, 14 and 28 days. The gingival crevicular fluid levels of osteocalcin and cross-linked C-terminal telopeptides of type I collagen were determined by using ELISA. The rate of tooth movement was measured on 14 and 28 days.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Class I, Class II or Class III malocclusion,
  • Proclined incisors requiring extraction of the maxillary first premolars with subsequent retraction of the maxillary canines
  • No previous orthodontic treatment
  • Good oral hygiene and periodontal health (plaque and gingival indices less or equal 1, probing depth less or equal 3 mm, no radiographic bone loss).

Exclusion criteria

  • having systemic diseases that could affect bone and tooth movement
  • smoking

Treatment and study plan

Piezocision

Procedure

Piezocisions were performed on the mesial and distal sides of the right maxillary canines. Then canine distalization was performed via closed-coil springs applying 150 g of force by using mini-screws as anchorage.

Control

Procedure

The mesial and distal sides of the left maxillary canines served as controls and canine distalization was performed via closed-coil springs applying 150 g of force by using mini-screws as anchorage.

Primary outcomes

  1. Gingival crevicular fluid osteocalcin level (ng/ml)

    Time frame: 28 days after canine distalization

    Gingival crevicular fluid samples were collected from mesial and distal sides of the maxillary right and left canines.The gingival crevicular fluid level of osteocalcin was determined by using ELISA

  2. Gingival crevicular fluid cross-linked C-terminal telopeptides of type I level (ng/ml)

    Time frame: 28 days after canine distalization

    Gingival crevicular fluid samples were collected from mesial and distal sides of the maxillary right and left canines.The gingival crevicular fluid level of cross-linked C-terminal telopeptides of type I collagen was determined by using ELISA.

Secondary outcomes

  1. The amount of canine movement (mm)

    Time frame: Baseline (day 0) before canine distalization and, 14 and 28 days after canine distalization

    All measurements were performed on the dental cast model using a digital caliper. The amount of space closure was based on the measurements of the distance between the contact points of the distal surface of canine and the mesial surface of second premolar. The change of distance between the three observation periods represented the amount of canine movement.

  2. Retraction rate (mm/day) of canine movement

    Time frame: 14 and 28 days after canine distalization

    All measurements were performed on the dental cast model using a digital caliper. The amount of space closure was based on the measurements of the distance between the contact points of the distal surface of canine and the mesial surface of second premolar. The change of distance between the three observation periods represented the amount of canine movement, which was divided by the number of days between two sessions to obtain the retraction rate on daily basis

Sponsors and collaborators

Lead sponsor

Marmara University

Other

Registry information

Official study title

Osteocalcin and Cross-Linked C-Terminal Telopeptides of Type I Collagen in Gingival Crevicular Fluid During Piezocision Accelerated Orthodontic Tooth Movement

Important dates

Study start
2013
Primary completion
2014
Study completion
2014
First posted
Nov 2, 2020
Registry last updated
Nov 2, 2020

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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