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Completed

NCT Number: NCT03400319

Obstructive Sleep Apnoea in Adolescents With Thoracic Aortic Aneurysm

The objective of this prospective cohort study is to determine the prevalence of obstructive sleep apnoea (OSA) in patients with and without thoracic aortic aneurysm.

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Key information

Conditions

Thoracic Aortic Aneurysm Without Rupture Aneurysm Aortic Aneurysm Aortic Aneurysm, Thoracic Aortic Diseases Apnea Cardiovascular Diseases Dyssomnias Nervous System Diseases Obstructive Sleep Apnea Respiration Disorders Respiratory Tract Diseases Sleep Apnea Syndromes Sleep Apnea, Obstructive Sleep Disorders, Intrinsic Sleep Wake Disorders Vascular Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

University Hospital Zurich, Pulmonary Division

Zurich, 8091, Switzerland

About this study

The objective of this prospective cohort study is to determine the prevalence of obstructive sleep apnoea (OSA) in patients with and without thoracic aortic aneurysm.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age > 18 years.
  • Diagnosis of thoracic aortic aneurysm defined by the following parameters:

Women: at the level of the sinus of valsalva ≥39mm, or ascending aorta ≥42mm. (for controls: <39mm and <42mm respectively); Men: at the level of the sinus of valsalva ≥44mm, or ascending aorta ≥46mm. (for controls: <44mm and <46mm respectively)

Exclusion criteria

  • Patients on continuous positive airway pressure (CPAP) therapy for OSA at baseline.
  • Patients with known central sleep apnoea.
  • Patients on morphine or other opioid medication, heroin addiction, alcohol addiction.
  • Patients with moderate or severe aortic regurgitation.
  • Patients with moderate or severe aortic stenosis.
  • Pregnant patients.

Treatment and study plan

Primary outcomes

  1. Prevalence of Obstructive Sleep Apnea

    Time frame: Baseline

    Prevalence of Obstructive Sleep Apnea according to a Sleep study (The ApneaLink™)

Sponsors and collaborators

Lead sponsor

University of Zurich

Other

Registry information

Acronym: OSA in TAA

Important dates

Study start
2014
Primary completion
2020
Study completion
2020
First posted
Jan 17, 2018
Registry last updated
May 3, 2021

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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