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OpenTrials
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NCT Number: NCT02518633

Obstructive Sleep Apnoea and Adipose Tissue Dysfunction

Dysfunctional adipose tissue predisposes to cardiovascular disease. Similarly, the risk of cardiovascular disease appears to be increased in subjects with obstructive sleep apnoea. Reduced adipose tissue oxygen availability has been described in obesity and may also be a mechanism in obstructive sleep apnoea. Hypoxia induces inflammation and fibrosis in adipose tissue which are factors contributing to cardiovascular risk. The investigators hypothesize that adipose tissue's oxygen uptake is reduced in subjects with obstructive sleep apnoea by comparing in vivo AT oxygenation and blood flow in tissue of control subjects.

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Key information

Conditions

Obstructive Sleep Apnoea Apnea Body Weight Dyssomnias Hypoxia Nervous System Diseases Nutrition Disorders Nutritional and Metabolic Diseases Obesity Overnutrition Overweight Pathological Conditions, Signs and Symptoms Respiration Disorders Respiratory Tract Diseases Signs and Symptoms Signs and Symptoms, Respiratory Sleep Apnea Syndromes Sleep Apnea, Obstructive Sleep Disorders, Intrinsic Sleep Wake Disorders

Age range

18 year–90 year

Sex eligibility

Male

Study type

Observational

Primary location

NIHR Clinical Research Facility, Exeter, United Kingdom

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About this study

Assessment includes a adipose tissue biopsy and measurement of oxygenation and blood flow by a Clarke type electrodes and non-invasive Doppler techniques.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • men with or without obstructive sleep apnoea

Exclusion criteria

  • weight loss interventions
  • steroid use
  • active smoking

Treatment and study plan

Continuous positive airway pressure devices

Device

overnight use of CPAP device

Other names: CPAP

Primary outcomes

  1. pO2 in adipose tissue by Clarke type electrode

    Time frame: 4 months

    Measurement of pO2 by Clarke type electrode

Secondary outcomes

  1. blood flow in adipose tissue by laser Doppler techniques

    Time frame: 4 months

    assessment of tissue blood flow by laser Doppler techniques

Other outcomes

  1. adipose tissue gene expression of HIF-1alpha

    Time frame: 4 months

    adipose tissue expression of hypoxia related genes

Sponsors and collaborators

Lead sponsor

Royal Devon and Exeter NHS Foundation Trust

Other

Collaborators

  • University of Exeter

Registry information

Official study title

Assessment of Hypoxia in Adipose Tissue of Subjects With Obstructive Sleep Apnoea

Important dates

Study start
2010
Primary completion
2015
Study completion
2015
First posted
Aug 10, 2015
Registry last updated
Feb 17, 2017

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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