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Completed

NCT Number: NCT04762914

Observing the Perioperative Effects of Prehabilitation in Colorectal Cancer Patients

Quality Improvement Project to evaluate how prehabilitation can be incorporated into our colorectal cancer pathway and assess its clinical benefits.

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Key information

Conditions

Colon Cancer Colonic Diseases Colonic Neoplasms Colorectal Neoplasms Digestive System Diseases Digestive System Neoplasms Gastrointestinal Diseases Gastrointestinal Neoplasms Intestinal Diseases Intestinal Neoplasms Neoplasms Neoplasms by Site

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Medway Hospitals NHS Trust

Gillingham, Kent, ME7 5NY, United Kingdom

About this study

The aim was to evaluate how prehabilitation (PH) can be incorporated into our colorectal cancer pathway and assess its clinical benefits.

Patients underwent PH (exercise, nutrition and psychological support) before resection of colorectal carcinoma in a DGH over fourteen months. Patients were matched by operation, age, sex and ASA to non-prehabilitation (NPH) patients using a prospectively maintained database. Length of stay (LoS) and complication rate and 90-day readmission rates were compared using Wilcoxon and McNemar's methods.

Prehabilitation significantly improved peak VO2 and AT. This corresponds to a reduction in predicted 30-day mortality. Despite a higher Charlson index LoS was unchanged suggesting prehabilitation may permit safe resection in comorbid patients.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Adults over the age of 18 who had prehabilitation for colorectal cancer

Exclusion criteria

  • Children
  • Patients who had prehabilitation but not for colorectal cancer

Treatment and study plan

Prehabilitation

Other

Prehabilitation is a multimodal and multidisciplinary person-centred perioperative approach involving supervised exercise training, nutritional education, management of polypharmacy and psychological advice.

Primary outcomes

  1. Length of stay

    Time frame: From date of operation to date of discharge in number of days over a 90 day follow up period

    Time spent in hospital

  2. Complication rate

    Time frame: Follow up over a period of 90 days following operation

    All Clavien-Dindo complications

Secondary outcomes

  1. Anaerobic threshold

    Time frame: CPET performed before prehabilitation and after prehabilitation (median of 36 days)

    Measured by looking at CPET results pre- and post- prehab

Sponsors and collaborators

Lead sponsor

Medway Primary Care Trust

Other Gov

Registry information

Official study title

Observing the Perioperative Effects of Prehabilitation in Colorectal Cancer

Important dates

Study start
2018
Primary completion
2019
Study completion
2019
First posted
Feb 21, 2021
Registry last updated
Feb 21, 2021

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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