OBSERVATIONAL STUDY ON VIRAL SHEDDING AND IMMUNOLOGICAL RESPONSE OF OROPOUCHE VIRUS

Results of the anti-OROV serum antibody response along the study period:

• IgM (titer, reciprocal of dilution);
• IgG (titer, reciprocal of dilution).

Results of OROV viral RNA presence in different matrice along the study period:

RT-PCR Ct and RNA copies/mL in different matrices: urine, whole blood, serum, vaginal swab or seminal fluid, CSF and amniotic fluid if available.

Results of the anti-OROV neutralizing antibody response along the study period:

neutralizing antibodies titer (titer, reciprocal of dilution).

Results of the quality of anti-OROV cell mediatedimmune response along the study period: specific cell-mediated response (specific IFN producing cells/100,000).

Results of the quality of anti-OROV cytokine production profile along the study period: cytokine analysis (pg/ml)

IgM and IgG kinetics (days from symptoms onset or first diagnosis).

RT-PCR positivity persistence (days from symptoms onset or first diagnosis)

Results of OROV RT-PCR testing results by cycle threshold (Ct) values along the study period: RT-PCR (Ct)

Results of OROV RNA copies along the study period: ddPCR (copies/mL)