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Completed

NCT Number: NCT01826253

Observational Study of Oxygen Delivery During a Fractional Fluid Expansion

Fluid expansion during cardiocirculatory insufficiency was helped by cardiac output monitoring. However, the goal of fluid expansion was to increase the oxygen delivery, which consider cardiac output, but also Haemoglobin which decrease during a fluid challenge. The maximalization of cardiac output could decrease the oxygen delivery if the haemodilution was too wide. The aim of this study was to describe the oxygen delivery during a fluid expansion conducted for cardiac output maximalization, following actual guidelines.

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Key information

Conditions

Hypovolemia Cardiac Output, Low Cardiovascular Diseases Heart Diseases Impaired Oxygen Delivery Pathologic Processes Pathological Conditions, Signs and Symptoms Signs and Symptoms

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

University Hospital of Caen

Caen, 14000, France

About this study

One group of 20 anticipated patients

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Adults over 18 years
  • Patients in intensive care after cardiac surgery under mechanically ventilation and with oesophageal Doppler

Exclusion criteria

  • Arrythmia
  • Pregnancy or childrens
  • Patients without cardiac output monitoring with oesophageal Doppler
  • Patients without medical indication for fluid expansion
  • Urgency surgery

Treatment and study plan

hydroxyethylstarch 130/0.4

Drug

Bolus of 100ml of HES 130/0.4 repeated until maximization of cardiac output

Primary outcomes

  1. Measurement of oxygen delivery

    Time frame: only during the fluid challenge

    Retrospective calculation of oxygen delivery (ml.min.m-2)during a fractional fluid expansion every 100ml of hydroxyethyl starch until cardiac output maximalization with oesophageal Doppler and arterial gazes (for PaO2 and Haemoglobin)from arterial line.

Secondary outcomes

  1. Study of central venous saturation

    Time frame: only during the fluid challenge

    Central venous gazes after each mini fluid challenge until cardiac output maximalization, from a central line

Other outcomes

  1. study of cerebral and muscular oxygenation measured with near-infrared spectroscopy

    Time frame: only during the fluid challenge

    study of cerebral and muscular oxygenation measured with near-infrared spectroscopy after each mini fluid challenge until cardiac output maximalization, from a central line

Sponsors and collaborators

Lead sponsor

University Hospital, Caen

Other

Registry information

Acronym: OR

Important dates

Study start
2013
Primary completion
2014
Study completion
2014
First posted
Apr 8, 2013
Registry last updated
Jun 16, 2014

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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