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Completed

NCT Number: NCT00338234

Observational Study of Iron Metabolism in Anemia in ICU and Post-Operative Patients

Anemia in intensive care and post-operative patients is due to both blood loss (leading to iron loss) and inflammation.

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Key information

Conditions

Anemia Cardiac Surgery Hematologic Diseases Hemic and Lymphatic Diseases Intensive Care

Age range

20 year–88 year

Sex eligibility

All sexes

Study type

Observational

Primary location

APHP, hopital Bichat

Paris, 75018, France

About this study

Anemia in intensive care and post-operative patients is due to both blood loss (leading to iron loss) and inflammation. The latter is known to interfere with iron metabolism, inducing iron storage instead of using it for hemoglobin synthesis. The discover of a new regulatory hormone of iron metabolism, hepcidin, may help us to better understand the link between inflammation and iron functional deficit. The aim of our study is to observe the variation of usual iron metabolism biological markers and of hepcidin, in order to define the better marker of iron loss in these clinical situations.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Anemia (haemoglobin < 10 g/dL)
  • Hospitalization in ICU for an expected duration of 7 days or more
  • Or, day one post cardiac surgery

Exclusion criteria

  • Chronic anemia (Hb < 9 g/dL for more than one month before hospitalization)
  • Iron metabolism disease

Treatment and study plan

Primary outcomes

  1. Functional iron deficiency

    Time frame: during the study

Secondary outcomes

  1. fatigue assessed by the MFI20 score for cardiac surgery patients

    Time frame: at one day,at seven days and at 28 days

Sponsors and collaborators

Lead sponsor

Assistance Publique - Hôpitaux de Paris

Other

Collaborators

  • Institut National de la Santé Et de la Recherche Médicale, France
  • Société Française d'Anesthésie et de Réanimation

Registry information

Official study title

Observational Study of Iron Metabolism in Anemia in ICU and Post-Operative Patients, Role of Hepcidin

Acronym: FAIRe

Important dates

Study start
2006
Primary completion
2007
Study completion
2007
First posted
Jun 20, 2006
Registry last updated
May 6, 2008

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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