Observational Study of Hunner's Ulcer in Patient With Interstitial Cystitis/Bladder Pain Syndrome

This is observational, 12 months study

Inclusion criteria

• must have experienced bladder pain, urinary urgency and urinary frequency, for at least 6 months prior to entry into the study
• Pain VAS ≥4
• O'Leary-Sant Interstitial Cystitis questionnaire (IC-Q) symptom and problem ≥ 12( and pain ≥2, and nocturia ≥ 2)
• PUF score ≥ 13
• cystoscopic record within 2 years
• Hunner ulcer lesion in cystoscopic finding

Exclusion criteria

• Scheduled for or use of intravesical therapy (eg, bladder distention,transurethral resection of bladder ulcer, instillation) during or within 6months prior to the study and use of pentosan polysulfate sodium within 1 months prior to the study
• Patients who are pregnancy or, childbearing age without no contraception
• Patients with voided volume <40 or, > 400ml
• Patients with microscopic hematuria, (≥1+ in dipstick), If not excluded that no evidence of neoplastic tumor examination
• Patients with urine culture showing evidence of urinary tract infection 1month prior to the study
• Accompanied medical problem below

• Tuberculosis in urinary system
• Bladder cancer, urethral cancer, prostate cancer
• Recurrent cystitis
• Anatomical disorder
• Patients had prior surgery (eq, bladder augmentation, cystectomy
• Patients with neurologic disorder
• Patients with indwelling catheter or intermittent self-catheterization
• Patients with psychologic problem