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Recruiting

NCT Number: NCT05919511

Observational Study for Patients at Risk for Chronic Graft-Versus-Host Disease

The purpose of this prospective observational study is to collect data from participants who have recently had an allogenic Stem Cell Transplant(alloSCT) and are at risk of Chronic Graft Versus Host Disease(cGVHD)

Recruiting

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Key information

Conditions

cGVHD Bronchial Diseases Bronchiolitis Bronchiolitis Obliterans Bronchiolitis Obliterans Syndrome Bronchitis Graft vs Host Disease Immune System Diseases Lung Diseases Lung Diseases, Obstructive Organizing Pneumonia Respiratory Tract Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

University of Alabama Birmingham, Birmingham, Alabama, United States

Loading trial locations.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age ≥ 18 years inclusive at the time of signing the ICF
  • Allogeneic SCT 90 to 180 days prior to enrollment
  • Able to comprehend and willing to provide informed consent
  • Willing and able to complete participant-assessment questionnaires either alone or with minimal assistance from a caregiver and/or trained site personnel

Exclusion criteria

  • There are no exclusion criteria for this study

Treatment and study plan

Non-Interventional

Other

This is an observational study

Primary outcomes

  1. Overall Burden of cGVHD diagnosis and severity

    Time frame: 36 months

Secondary outcomes

  1. To describe personal and healthcare resources associated with the management of cGVHD

    Time frame: 36 months

  2. To describe changes in the proteomic, cytologic and molecular profile in blood, serum and saliva cGVHD

    Time frame: Up to 36 months

Study contacts

Contact information is provided by the study sponsor or research team.

Incyte Corporation Call Center (US)

CONTACT

[email protected]

1.855.463.3463

Incyte Corporation Call Center (ex-US)

CONTACT

[email protected]

+800 00027423

Sponsors and collaborators

Lead sponsor

Incyte Corporation

Industry

Registry information

Official study title

A Prospective, Observational Cohort Study of Participants at Risk for Chronic Graft-Versus-Host Disease in the United States (THRIVE)

Acronym: THRIVE

Important dates

Study start
2023
Primary completion
2027
Study completion
2027
First posted
Jun 26, 2023
Registry last updated
Mar 24, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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