Objective Systolic Function Recuperation Assessed by Echocardiography

The purpose of this study is to evaluate left ventricular systolic ejection fraction and anterior or apical akinesis 1 month and 3 months after a myocardial infarction treated with primary PCI to determine whether improvement at 1 month differs from improvement at 3 months.

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Key information

Conditions

Myocardial Infarction Anterior Akinesis Apical Akinesis Arterial Occlusive Diseases Arteriosclerosis Cardiovascular Diseases Coronary Artery Disease Coronary Disease Heart Diseases Heart Failure Infarction Ischemia Left Ventricular Systolic Dysfunction Myocardial Ischemia Necrosis Pathologic Processes Pathological Conditions, Signs and Symptoms ST Elevation Myocardial Infarction Vascular Diseases Ventricular Dysfunction Ventricular Dysfunction, Left

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Centre hospitalier universitaire de Sherbrooke

Sherbrooke, Quebec, J1H 5N4, Canada

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Older than 18 years old
ST elevation myocardial infarction treated with primary PCI
Anterior or apical akinesis and left ventricular ejection fraction ≤ 45% on early echocardiography (48hours - 7 days post myocardial infarction)
Initial ECG showing at least 1 mm ST elevation in 2 leads corresponding to the same vascular territory

Exclusion criteria

Known left ventricular systolic dysfunction before myocardial infarction
Left bundle branch block
Vital prognosis less than 6 months
Cardiogenic shock
Rescue PCI
Sub-optimal echocardiographic imaging (contrast use is allowed)
Significant valvular heart disease (moderate or severe)
Surgical revascularization
Pregnancy or breastfeeding
Incapacity to provide informed consent

Treatment and study plan

Primary outcomes

Left ventricular ejection fraction recuperation 1 month post myocardial infarction

Time frame: 1 month post myocardial infarction

Left ventricular ejection fraction recuperation 1 month post myocardial infarction as compared with the left ejection fraction 3 months post myocardial infarction

Secondary outcomes

Anterior and apical akinesis recuperation 1 month post myocardial infarction

Time frame: 1 month post myocardial infarction

Anterior and apical akinesis recuperation 1 month post myocardial infarction as compared with 3 months post myocardial infarction

Sponsors and collaborators

Lead sponsor

Paul Farand

Other

Registry information

Acronym: ROSE

Important dates

Study start: 2010
Primary completion: 2012
Study completion: 2012
First posted: Mar 12, 2010
Registry last updated: Jul 8, 2013

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed