Obesity-related Genes in Taiwanese Undergoing Weight Loss

To investigate:

1. Associations between miRNA and insulin signaling-related gene expressions in abdominal adipose tissues in obese subjects. 2. Differences in miRNAs expressed by intrabdominal omental adipose tissues between genders.

Completed

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Key information

Conditions

Morbid Obesity Body Weight Nutrition Disorders Nutritional and Metabolic Diseases Obesity Obesity, Morbid Overnutrition Overweight Pathological Conditions, Signs and Symptoms Signs and Symptoms

Age range

19 year–63 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Taipei Medical University Hospital

Taipei, Taiwan, 110

About this study

Compared the differences in microRNA expressions of abdominal adipose tissue in morbid obese male and female subjects to elucidate the possible regulatory role of microRNA in insulin signaling-related gene expression levels and its association with biochemical markers. We hope to find a miRNA that can be used to predict the syndrome associated with obesity.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Morbid obesity,BMIs> 40 kg/m2
Subjects who underwent bariatric surgery

Exclusion criteria

Obese subjects with complicated metabolic disorders
Thyroid disease

Treatment and study plan

gender

Genetic

Paired samples of abdominal subcutaneous and intrabdominal omental adipose tissue were obtained from men and women who underwent bariatric surgery.

Other names: BMI were all over 40 kg/ m2

Primary outcomes

MicroRNA expression in abdominal omental adipose tissues

Time frame: up to 28 weeks

MicroRNA-125a-3p expression in abdominal omental adipose tissues is associated with insulin signaling-related gene expression levels in morbid obesity

Sponsors and collaborators

Lead sponsor

Sung Ling Yeh

Other

Collaborators

National Science and Technology Council, Taiwan

Registry information

Official study title

Searching for the Most Influential Obesity-related Diabetic Genes and Exploring the Expression Profiles of Those Genes in Taiwanese Undergoing Weight Loss

Important dates

Study start: 2010
Primary completion: 2010
Study completion: 2010
First posted: Sep 12, 2012
Registry last updated: Sep 13, 2012

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed