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NCT Number: NCT07472608

Obesity Medicine Bank of the Quebec Heart and Lung Institute - Laval University (IUCPQ-ULaval)

Obesity medicine, or bariatric medicine, focuses not only on the biological and behavioral aspects, but also on the environmental and social factors that contribute to the development of obesity. Many diseases are associated with obesity, such as type 2 diabetes, hypertension, cardiovascular diseases, numerous cancers, gynecological disorders, etc. Focusing on obesity medicine is crucial for improving patients' quality of life, reducing healthcare costs, and developing effective prevention strategies. The Quebec Heart and Lung Institute - Laval University (IUCPQ-ULaval) maintains a clinical database and biological material bank for studying the multidisciplinary management of obesity and its complications.

A biobank is a collection of information, clinical or biochemical data (including radiological, cardiac, and genetic data), and blood samples concerning donors. The information that can be collected includes, for example, age, sex, diagnosis, progression or treatment of a medical condition, medications, DNA, etc. DNA is a molecule present in all cells and contains all the information necessary for the development and functioning of our body.

This bank aims to better characterize patients' profile receiving follow-up care in obesity medicine, identify predictive factors of success or failure of interventions and adapt management strategies according to specific needs. The collected data and blood samples will be used in several research projects with the following objectives:

1. To document the socioeconomic, demographic, clinical, radiological, genetic, and biochemical characteristics of patients living with obesity and requiring medical follow-up at the bariatric medicine clinic at the IUCPQ-ULaval 2. To explore the effects or associations of genetic and biochemical determinants on health in the context of obesity 3. To gain a better understanding of the pathophysiology and genes involved in obesity and associated metabolic abnormalities 4. To evaluate the clinical utility of non-invasive biomarkers in the screening of preclinical obesity and its comorbidities and/or 5. To evaluate the effectiveness of medications, health behavior changes, and bariatric surgery in order to develop optimal interventions aimed at improving the health and medical management of people with obesity.

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Key information

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Centre de recherche de l'Institut universitaire de cardiologie et de pneumologie de Québec

Québec, Quebec, G1V 4G5, Canada

Location contact

Audrey St-Laurent, PhD

CONTACT

[email protected]

418-656-8711 ext. 2681

Fannie Lajeunesse-Trempe, MD PhD FRCPC

PRINCIPAL_INVESTIGATOR

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

To be included in the registry (database + biobank), a person must first be referred to the Bariatric Medicine Clinic at the IUCPQ-ULaval and meet several criteria:

  • Be over 18 years of age
  • Meet at least one of the following five criteria:
  • Body mass index ≥30 kg/m2 with or without comorbidities (preclinical or clinical obesity);
  • Require weight loss related to a transplant, bariatric surgery, or another type of surgery (e.g., hernia repair, orthopedic surgery, neurosurgery, etc.);
  • History of bariatric surgery resulting in weight regain of at least 15% of the total weight lost;
  • History of bariatric surgery resulting in weight loss deemed insufficient by the treating medical team;
  • Having undergone bariatric surgery with complications related to it (i.e., flushing syndrome or hypoglycemia, nephrolithiasis, return of comorbidities in remission, abnormalities in phosphocalcic balance and vitamin deficiencies).

Treatment and study plan

Behavioral and Pharmacological Treatments

Other

Behavioral and pharmacological treatments are part of the standard of care and will vary among individuals based on their specific needs.

Primary outcomes

  1. Success or failure of obesity medicine interventions

    Time frame: Baseline to 15-year follow-up. Follow-up is based on standard care consultations which vary from a patient to another

    • Anthropometric Parameters: weight and height combined to obtain BMI (kg/m^2). Waist circumference (cm); Body composition assessed by bioelectrical impedance analysis
    • Cardiometabolic Parameters and Comorbidities: Hepatic steatosis and fibrosis assessed by controlled attenuation parameter (CAP) and liver stiffness measurement (transient elastography); Liver biochemical parameters (e.g., ALT, AST, GGT); Lipid profile (total cholesterol, LDL-C, HDL-C, triglycerides); Inflammatory markers (as available in medical records); Glycemic parameters (fasting glucose, HbA1c, insulin, as available); Polysomnography parameters (when available); Echocardiographic parameters (when available)
    • Adoption of Lifestyle Intervention: Documented adherence and engagement in prescribed lifestyle interventions, as reported in medical charts
    • Quality of Life: Clinician-documented quality-of-life assessment, as recorded in medical charts
    • Mental Health Parameters: As recorded in medical charts

Study contacts

Contact information is provided by the study sponsor or research team.

Audrey St-Laurent, PhD

CONTACT

[email protected]

418-656-8711 ext. 2681

Fannie Lajeunesse-Trempe, MD PhD FRCPC

CONTACT

[email protected]

418-656-8711 ext. 8052

Sponsors and collaborators

Lead sponsor

Institut universitaire de cardiologie et de pneumologie de Québec, University Laval

Other

Collaborators

  • Eli Lilly and Company

Registry information

Official study title

Database and Biological Material Bank in Obesity Medicine of the Quebec Heart and Lung Institute - Laval University (IUCPQ-ULaval)

Important dates

Study start
2026
Primary completion
2051
Study completion
2051
First posted
Mar 16, 2026
Registry last updated
Mar 16, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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