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NCT Number: NCT06644911

Obesity Doppler in Term Pregnancy

Maternal obesity is an epidemic in the developed world like Egypt. There are many pregnancy-associated complications including pre-eclampsia, gestational diabetes, and increased rates of septic wound after cesarean delivery. As a potential explanation of the etiology of complications due to maternal obesity, the role of endothelial dysfunction in the systemic and peripheral vasculatures has been hypothesized. It has been proposed that some adverse pregnancy outcomes in obese patients may be mediated by placental insufficiency. Utero-placental insufficiency is typically associated with fetal growth restriction and low birth weight.

Umbilical and uterine artery Doppler is widely accepted as a useful tool for monitoring high-risk pregnancies.

Normally, uterine artery vascular impedance gradually decreases until the late mid-trimester, owing to the establishment of a low-resistance placental circulation. Obesity has little impact on uterine vascular changes reflected by the early uterine artery PI. However, in the second trimester, extreme obesity appears to impair the normal continued drop in uterine vascular resistance. Many studies have examined the relationship between BMI and Doppler changes in high-risk pregnancies, but few have addressed these changes in low-risk pregnancies.

Recruiting

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Key information

Age range

20 year–35 year

Sex eligibility

Female

Study type

Observational

Primary location

Woman's Health Hospital - Assiut university

Asyut, 71111, Egypt

Location status: Recruiting

Location contact

Mohammed K ALi, MD

CONTACT

[email protected]

+201005537951

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Singleton pregnancy
  • Gestational age ≥ 37 weeks
  • Absence of fetal structural abnormalities
  • Absence of maternal comorbidities and/or complications.
  • Obese women (BMI ≥ 30 kg/m2) [11].
  • Normal weight (BMI 18.5-24.9) [11].

Exclusion criteria

  • Placenta previa
  • Women with antepartum hemorrhage.
  • Smokers and alcohol consumers
  • Preeclampsia
  • Diabetes mellitus
  • Women need urgent termination of pregnancy.

Treatment and study plan

Primary outcomes

  1. The difference between uterine and umbilical artery Doppler resistant index

    Time frame: at 37 weeks of pregnancy

    The difference between uterine and umbilical artery Doppler indices between normal weight and obese pregnant women ≥ 37 weeks.

Study contacts

Contact information is provided by the study sponsor or research team.

Mohammed Khairy Ali, MD

CONTACT

[email protected]

01005537951

Sponsors and collaborators

Lead sponsor

Assiut University

Other

Registry information

Official study title

The Effect of Maternal Obesity on Umbilical and Uterine Artery Doppler in Term Pregnancy : a Cross-sectional Study

Important dates

Study start
2025
Primary completion
2026
Study completion
2026
First posted
Oct 16, 2024
Registry last updated
Jan 28, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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