Obesity and the Initiation of Knee Osteoarthritis

Healthy adults aged 20-60 of varying weights will participate in this minimally invasive study. There is one 4-hour appointment for which subjects are paid $120. The tests involve: 1 tube blood draw, 1 gait test (motion capture) and 1 MR of both knees.

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Key information

Conditions

Obesity Arthritis Body Weight Joint Diseases Musculoskeletal Diseases Nutrition Disorders Nutritional and Metabolic Diseases Overnutrition Overweight Pathological Conditions, Signs and Symptoms Signs and Symptoms

Age range

20 year–60 year

Sex eligibility

All sexes

Study type

Observational

Primary location

VA Palo Alto Health Care System

Palo Alto, California, 94304-1290, United States

About this study

The tests will be done at the VA and Stanford and are not dangerous or painful. They are designed to help us learn more about the relationship of excess weight on cartilage degradation by testing a biomarker in blood. Gait testing involves walking in a lab that is about 20 meters long about 20 times. MR involves lying in a tube for less than 1 hour.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Healthy Adults aged 20-60 who have no history of LE surgery
Healthy adults able to walk 30 minutes
Healthy adults able to have MR

Exclusion criteria

Adults who have had LE surgery
Adults cannot walk 30 minutes
Adults who cannot tolerate MR
Adults with osteoarthritis

Treatment and study plan

Primary outcomes

Gait Knee Adduction Moment

Time frame: baseline or first and only visit.
Cartilage Thickness

Time frame: baseline or first and only visit.

Medial/lateral thickness ratio

Sponsors and collaborators

Lead sponsor

US Department of Veterans Affairs

Fed

Registry information

Official study title

Obesity and Initiation of Osteoarthritis

Important dates

Study start: 2009
Primary completion: 2012
Study completion: 2012
First posted: Mar 6, 2009
Registry last updated: Dec 19, 2014

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed