O-RADS MRI System on Early Detection of Ovarian Cancer

Inclusion criteria

• Patients meeting either of the following criteria based on initial diagnostic pelvic ultrasound findings (pelvic mass or pelvic effusion) suspicious for ovarian malignancy or at elevated risk for ovarian cancer:

• Postmenopausal women or females ≥45 years with pelvic mass or effusion on ultrasound;
• Postmenopausal women or females ≥45 years with serum CA125 ≥35 U/mL;
• Females ≥35 years with a confirmed family history of ovarian or breast carcinoma;
• Females ≥35 years harboring pathogenic/likely pathogenic BRCA1/2 germline mutations;
• Females ≥35 years with BRCA1/2 mutations, non-suspicious adnexal lesions on ultrasound but planning prophylactic adnexectomy with availability of serial pathological sectioning.

② Ability to comply with the study protocol and adhere to scheduled follow-up assessments.

③ Provision of written informed consent.

Exclusion criteria

• ① Pregnant individuals

• Patients with histopathologically confirmed ovarian cancer

• Ovarian malignancy diagnosed by PET-CT at this institution

④ Patients undergoing neoadjuvant chemotherapy for confirmed ovarian cancer

⑤ Claustrophobia precluding tolerance of MRI examination

⑥ Contraindications to MRI: cardiac pacemakers, ferromagnetic implants, or high-risk metallic foreign bodies

⑦ History of gadolinium-based contrast agent (GBCA) hypersensitivity or intolerance

⑧ Severe renal insufficiency (glomerular filtration rate <30 mL/min/1.73 m²)