Nutritional Evaluation of Infants Receiving Amino Acid-Based Formula

This prospective observational study will assess infants who are exclusively fed amino acid-based formula. Participants will be followed over a period of 6 months, and anthropometric measurements (weight, length, head circumference) will be recorded monthly. Growth velocity and nutritional status will be analyzed and compared with WHO growth standards.

Inclusion criteria

• Infants aged 1 to 12 months at the time of enrollment.
• Infants who are exclusevel or predominantly fed amino acid-based formula (AAF) in addition to elimination diet for at least 12 consecutive weeks.
• Infants who are diagnosed as CMPA by CoMiSS score ≥ 10 and confirmed by OFC test.
• Infants with informed parental or guardian consent to participate in the study.

Exclusion criteria

• 1- Infants with congenital anomalies or syndromes affecting growth and development (e.g., trisomy 21, major cardiac defects).

2- Infants with chronic systemic illnesses unrelated to feeding (e.g., cystic fibrosis, chronic kidney disease).

3- Infants receiving additional specialized nutrition support (e.g., parenteral nutrition or tube feeding not involving AAF).

4- Infants with incomplete or insufficient medical records at the time of assessment.5- Infants who have been on AAF for less than 4 weeks or whose feeding regimen is not stable.

6- Infants whose parents or legal guardians decline or withdraw informed consent.