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Completed

NCT Number: NCT01415973

Nutrient Synergy in Beef and Stimulation of Protein Synthesis in Elderly

This study will compare the effects of cooked, ground beef to those of beef protein isolate on blood and muscle proteins.

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Key information

Conditions

Healthy

Age range

60 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

UAMS Center on Aging

Little Rock, Arkansas, 72205, United States

About this study

STUDY OBJECTIVES Primary: To compare the effects of consumption of a 3-ounce serving of beef to that of a 20g serving of BPI on skeletal muscle synthetic and breakdown rate in healthy elderly subjects.

Secondary: To investigate the effect the study products on plasma levels of amino acids, insulin, and glucose in healthy elderly subjects.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Healthy male or female.
  • Age 60 years or older.

Exclusion criteria

  • Any (history of) gastrointestinal disease that interferes with GI function
  • Diagnosed and active treatment of Diabetes Mellitus type I or II
  • History of congestive heart failure
  • Recent (6 months) hospitalization for heart disease treatment or management (e.g. PTCA, stent, surgery)
  • Myocardial infarction in the past year
  • Infection or fever in the 7 days prior to enrollment
  • Current use of corticosteroids, growth hormone, or testosterone
  • Adherence to a weight loss diet
  • Use of protein-containing or amino acid-containing nutritional supplements within one week of enrollment
  • Current alcohol (>7 ETOH per week) or drug abuse
  • Platelet count (PLT) < 100,000
  • History of hypo- or hyper-coagulation disorders including use of a coumadin derivative
  • Currently taking anti-thrombotics and cannot stop for 7 days (i.e. medical indication)
  • Allergy to local anesthetic
  • Blood hemoglobin < 9.0 g/dL
  • Investigator's uncertainty about the willingness or ability of the subject to comply with the protocol requirements

Treatment and study plan

3 ounces of cooked, 85% lean ground beef

Dietary Supplement

Consumed once per subject.

20 grams beef protein isolate

Dietary Supplement

Subjects would drink 200 ml water mixed with 20 grams of beef protein isolate one time.

Primary outcomes

  1. skeletal muscle synthetic and breakdown rate

    Time frame: day one

    Using stable isotope infusion/ingestion methodology, we will measure plasma and skeletal muscle metabolic rate. Our primary end points will be muscle protein fractional synthesis rate (FSR) and whole body protein turnover rate.

Secondary outcomes

  1. concentrations of plasma amino acids, insulin and glucose

    Time frame: day one

    Secondary endpoints are concentrations of plasma amino acids, insulin and glucose.

Sponsors and collaborators

Lead sponsor

University of Arkansas

Other

Registry information

Important dates

Study start
2011
Primary completion
2011
Study completion
2012
First posted
Aug 12, 2011
Registry last updated
Jan 18, 2012

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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