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Completed

NCT Number: NCT03561337

Nutrient Supplementation Influences Mitochondria Adaptation

Twenty-four well trained runners (VO2max 60.73.7 ml O2 Kg-1 min1) completed a six week block randomized controlled intervention period. Subjects were randomly assigned to either PRO-CHO or CHO and matched in pairs for gender, age, VO2max, training and performance status. The PRO- CHO group ingested a protein beverage (0.3g kg-1) before and protein-carbohydrate beverage (0.3g protein kg-1 and 0.1g carbohydrate kg-1) after each exercise session. The CHO group ingested energy matched carbohydrate. Post-absorptive muscle biopsies were obtained pre and post intervention for analysis HAD, CS and PGC-1. Subjects completed two physical tests 6 km performance test (pre, week 1 and week 6) and aVo2max test (pre and post intervention).

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Key information

Conditions

Performance Nutrition Protein

Age range

18 year–55 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Aarhus University, Department for Public Health, Section for Sport Science, Aarhus, Denmark

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Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • maximal oxygen uptake (VO2max) of >50ml O2 kg-1 min-1 for women and >55ml O2 kg-1 min-1 for men,
  • running at least 3 times a week and
  • running being the primarily training form

Exclusion criteria

  • use of medicine
  • diagnosed metabolic diseases
  • injuries which hindered running and body mass index (BMI) < 25 kg m-2

Treatment and study plan

PROTEIN-CARBOHYDRATE

Dietary Supplement

PRO before and PRO-CHO after training

CARBOHDYRATE

Dietary Supplement

CHO before and after training

Primary outcomes

  1. Maximal oxygen uptake

    Time frame: Change from week 1 to week 6

    maximal oxygen uptake (L O2/min)

Secondary outcomes

  1. VDAC

    Time frame: Change from week 1 to week 6

    Mitochondria target measured by western blotting

  2. CytC

    Time frame: Change from week 1 to week 6

    Mitochondria enzyme measured by western blotting

  3. Performance

    Time frame: Change from week 1 to week 6

    6 km trial test

  4. COX-IV

    Time frame: Change from week 1 to week 6

    Mitochondria target measured by western blotting

  5. HSP60

    Time frame: Change from week 1 to week 6

    Mitochondria target measured by western blotting

  6. CD36

    Time frame: Change from week 1 to week 6

    Fat transporter measured by western blotting

Sponsors and collaborators

Lead sponsor

University of Aarhus

Other

Registry information

Official study title

Effect of Whey Protein Hydrolysate on Adaptions to Endurance Training in Well-trained Runners

Important dates

Study start
2013
Primary completion
2014
Study completion
2014
First posted
Jun 19, 2018
Registry last updated
May 14, 2020

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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