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NCT Number: NCT07489859

Nurse vs Physician Artery Cannulation

This prospective controlled clinical trial evaluates the effectiveness and safety of radial artery cannulation using the Seldinger technique under ultrasound guidance when performed by two different operator groups: experienced physicians and trained registered nurses. The study aims to determine whether a structured, competency-based training program enables nurses without prior experience in arterial cannulation to achieve comparable outcomes to physicians in terms of first-attempt success rate, procedural efficiency, and complication rates.

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Key information

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

About this study

This study is a prospective, controlled clinical trial designed to compare the performance of radial artery cannulation using the Seldinger technique under ultrasound guidance between two predefined operator groups: experienced physicians and trained registered nurses. The trial is conducted in tertiary-care hospital settings in accordance with the Declaration of Helsinki and Good Clinical Practice guidelines. 

Radial artery cannulation is a commonly performed invasive procedure used for continuous blood pressure monitoring and arterial blood sampling in perioperative and critical care settings. While traditionally performed by physicians, task-sharing strategies supported by structured training programs may expand procedural capacity while maintaining patient safety. 

In this study, physicians in the control group are board-certified anaesthesiologists or intensivists with established experience in arterial cannulation. The intervention group consists of registered nurses who have no prior experience with arterial cannulation but have successfully completed a structured, competency-based educational program. This program incorporates theoretical instruction, simulation-based training, and supervised clinical practice, based on principles of deliberate practice and mastery learning. 

All procedures are performed using a standardized Seldinger technique with ultrasound guidance and identical equipment, under uniform clinical conditions. Patient preparation, sterile technique, and procedural protocols are standardized across both groups. A supervising physician is immediately available during all procedures to ensure patient safety. 

The primary outcome is first-attempt success rate, defined as successful arterial cannulation following a single skin puncture with confirmation by arterial waveform. Secondary outcomes include total procedure time, overall success rate, number of attempts, and incidence of complications such as hematoma, catheter dysfunction, distal ischemia, and need for rescue intervention. 

The study aims to determine whether nurses trained through a structured educational program can achieve procedural outcomes comparable to experienced physicians. The findings may support the implementation of competency-based training pathways and task-sharing models in vascular access procedures, potentially improving healthcare efficiency while maintaining high standards of patient safety. 

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Nurse with successful completion of the predefined radial artery catheterization educational module
  • Czech board certified anaesthesiologist with obtained competency for radial artery catheterization.

Exclusion criteria

  • Absence of competency for radial artery catheterization.

Treatment and study plan

Radial artery catheterization done by nurse

Procedure

Cannulation of a radial artery using Seldinger method by nurse.

Radial artery catheterization done by physician

Procedure

Cannulation of a radial artery using Seldinger method by physician.

Primary outcomes

  1. First successful attempt

    Time frame: From the first puncture of the patient's skin until the end of catheterization for maximum time of 20 minutes

    Number of first successful attempt

Secondary outcomes

  1. Time to complete catheterization

    Time frame: From the first puncture of the patient's skin until the end of catheterization for maximum time of 20 minutes

    Time from firs puncture of a patient's skin to complete successful catheter insertion.

  2. Complication rate

    Time frame: From the first puncture of the patient's skin until the extraction of the catheter for maximum time of 7 days

    Number of complications related to radial artery catheterization.

Sponsors and collaborators

Lead sponsor

Masarykova Nemocnice v Usti nad Labem, Krajska Zdravotni a.s.

Other

Registry information

Official study title

Nurse-performed Versus Physician-performed Radial Artery Cannulation: a Multicenter Randomized Non-inferiority Trial

Acronym: ARTEDU

Important dates

Study start
2026
Primary completion
2027
Study completion
2028
First posted
Mar 24, 2026
Registry last updated
Mar 31, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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