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NCT Number: NCT00410293

NT-proBNP in Acute Dyspnea: Effects on Treatment, Hospitalisation and Costs

Diagnostic uncertainty in patients with complaints of shortness of breath presenting to the Emergency Department of a hospital may delay treatment and proper care. In patients with shortness of breath due to heart failure increased plasma levels of NT-pro-B-type natriuretic peptide (NT-proBNP) can be demonstrated. The use of NT-proBNP as a biomarker for heart failure in patients presenting to the emergency department with dyspnea might improve care and reduce length of hospital stay.

To investigate the effect of NT-proBNP testing on patient care and time to discharge the NT-proBNP test will be randomized. In patients in the study group, the NT-proBNP plasma level is determined at admission and the physician in charge will immediately receive the result of the test. In patients in the control group blood will be sampled but the physician will recieve no information on the NT-proBNP plasma level.

In our study we will investigate the effect of introduction of NT-proBNP as biomarker for heart failure on treatment, time to discharge and costs.

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Key information

Conditions

Heart Failure Cardiovascular Diseases Disease Dyspnea Heart Diseases Pathologic Processes Pathological Conditions, Signs and Symptoms Respiration Disorders Respiratory Tract Diseases Signs and Symptoms Signs and Symptoms, Respiratory

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Erasmus MC

Rotterdam, 3015 CE, Netherlands

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age 18 years or older
  • Acute dyspnea as their most prominent complaint

Exclusion criteria

  • Acute dyspnea due to a trauma
  • Acute dyspnea due to cardiogenic shock
  • Renal failure requiring dialysis

Treatment and study plan

NT-proBNP testing

Procedure

Primary outcomes

  1. Time to discharge

  2. Cost of treatment

Secondary outcomes

  1. Duration of stay at the ED

  2. Proportion of patients admitted to the hospital

  3. Proportion of patients admitted to an intensive or coronary care unit

  4. Specialist consultations

  5. Medical treatment

  6. Diagnostic investigations

Sponsors and collaborators

Lead sponsor

Erasmus Medical Center

Other

Registry information

Official study title

NT-proBNP Testing in Patients Presenting to the Emergency Department With Acute Dyspnea: Evaluation of Effects on Treatment, Hospitalisation Rate and Costs

Important dates

Study start
2004
Study completion
2006
First posted
Dec 12, 2006
Registry last updated
Dec 12, 2006

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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