Skip to main content
OpenTrials
Active, Not Recruiting

NCT Number: NCT05026632

NPI-002 Intravitreal Implant for the Delay of Cataract Progression

This study will examine the safety and efficacy NPI-002 intravitreal implants post vitrectomy.

Active, Not Recruiting

This study is active but is not currently recruiting participants.

Notify Me

Key information

Conditions

Cataract Eye Diseases Lens Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 1 / Phase 2

Primary location

Royal Adelaide Hospital

Adelaide, Australia

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Indicated for vitrectomy
  • Natural Lens in place at time of vitrectomy
  • Some cataract present as assessed pre-operatively

Exclusion criteria

  • Previous intraocular surgery in study eye.
  • Clear zonular weakness or defects / coloboma.
  • Not on stable dose of medications for other conditions.
  • Need for oral corticosteroids during study participation.
  • Evidence or history of uveitis, or ocular ischemia.
  • Current smoker
  • Use of supplemental oxygen
  • Evidence or history of proliferative diabetic retinopathy.
  • Current lung disease (PU, COPD, Asthma) resulting in decreased oxygen saturation.
  • Sensitivity to thiol compounds.
  • Participation in another clinical trial.

Treatment and study plan

NPI-002 Intravitreal Implant

Drug

Implant inserted during vitrectomy.

Primary outcomes

  1. Lens Densitometry

    Time frame: 6 months

    Change from Baseline

Sponsors and collaborators

Lead sponsor

Nacuity Pharmaceuticals, Inc.

Industry

Registry information

Official study title

Safety and Efficacy of NPI-002 Intravitreal Implant for the Delay of Cataract Progression in Patients Undergoing Vitrectomy

Important dates

Study start
2022
Primary completion
2026
Study completion
2026
First posted
Aug 30, 2021
Registry last updated
Apr 13, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.