Novel MRI Techniques in the Evaluation of Pulmonary Vascular Disease

The diagnosis of a patient with pulmonary hypertension (PH) requires many investigations. At present cardiac catheterisation is the cornerstone investigation in these patients where it is used to establish disease severity and estimate prognosis. It is an invasive procedure which is expensive and not without risk to the patient. Despite the multitude of tests performed, identifying those patients with PH who have a poor diagnosis can be difficult. The aim of this study is to improve the assessment of patients with PH using novel magnetic resonance techniques.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Pulmonary Hypertension Cardiovascular Diseases Hypertension Hypertension, Pulmonary Lung Diseases Respiratory Tract Diseases Vascular Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 1 / Phase 2

Primary location

Sheffield Pulmonary Vascular Disease Unit, Royal Hallamshire Hospital

Sheffield, South Yorkshire, S10, United Kingdom

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

All cases referred to the clinic for assessment for possible pulmonary hypertension.

Exclusion criteria

patients with a cardiac pacemaker or retained temporary pacing wire
patients with aneurysm clip
non MRI compatible heart valve prosthesis
intra orbital metalic foreign body
pregnancy
metal prosthesis/spinal rods
retained shrapnel
cochlear implants/bladder stimulator

Treatment and study plan

3-Helium gas

Other

3-Helium gas for MRI contrast

Primary outcomes

pulmonary artery diameter (mm)

Time frame: up to 3 months

Three-dimensional MRI imaging will be used to acquire cardiac dimensions and anatomical ventilation distribution as well as regional partial pressures of oxygen in the lungs.

Sponsors and collaborators

Lead sponsor

Sheffield Teaching Hospitals NHS Foundation Trust

Other

Collaborators

University of Sheffield

Registry information

Important dates

Study start: 2010
Primary completion: 2015
Study completion: 2015
First posted: Jan 3, 2014
Registry last updated: Sep 30, 2015

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed