Skip to main content
OpenTrials
Recruiting

NCT Number: NCT06681818

Novel Method to Assess Hepatic Regeneration and Predict Hepatic Related Morbidity After Partial Hepatectomy

the investigators will pursue two specific aims: (1) to monitor the extent of heme oxygenase induction (by measuring endogenous CO production) in relationship to the extent of hepatic resection (2) to assess the production of CO in patients following liver resection and correlate these findings to the rate of liver regeneration and liver function.

Recruiting

Interested in participating?

Request Info

Key information

Conditions

Liver Cancer Adult Adenocarcinoma Carcinoma Carcinoma, Hepatocellular Digestive System Diseases Digestive System Neoplasms Liver Diseases Liver Neoplasms Liver Regeneration Neoplasms Neoplasms by Histologic Type Neoplasms by Site Neoplasms, Glandular and Epithelial

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patient plans to have partial liver resection for primary liver pathology or metastatic disease
  • Patient is able to comprehend and willing to sign the written consent form

Exclusion criteria

  • Patients < 18 years
  • Patients identified as members of a vulnerable population, except women of child bearing potential with negative pregnancy test

Treatment and study plan

carbon monoxide measurement via smokerlyzer

Other

participants in this study will provide breath samples for carbon monoxide measurements pre and post liver resection

Primary outcomes

  1. correlation of carbon monoxide levels in exhaled breath with quantity and quality of liver regeneration

    Time frame: measurements will be taken pre, then 4 hours and 24 hours post resection

    patients will be asked to donate exhaled breath into a smokerlyzer device

Secondary outcomes

  1. level of carbon monoxide in exhaled air of patients

    Time frame: measurements will be taken pre, then 4 hours and 24 hours post resection

    patients will be asked to donate exhaled breath into a smokerlyzer device

  2. quantity of liver regeneration, liver volume (ml)

    Time frame: one and three months after resection

    CT liver volumetric studies

  3. quality of hepatic regeneration, normalized liver function

    Time frame: one and three months post resection

    serum protein, albumin, AST and ALT, alkaline phosphatase, and bilirubin level

Study contacts

Contact information is provided by the study sponsor or research team.

Jamie Ketas

CONTACT

[email protected]

2018943418

Raquel Molina

CONTACT

[email protected]

Sponsors and collaborators

Lead sponsor

Englewood Hospital and Medical Center

Other

Registry information

Official study title

Postoperative Heme Oxygenase Induction and Carbon Monoxide Production as a Novel Method to Assess Hepatic Regeneration and Predict Hepatic Related Morbidity After Partial Hepatectomy

Important dates

Study start
2025
Primary completion
2039
Study completion
2039
First posted
Nov 8, 2024
Registry last updated
Jul 23, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.