Novel Method of Surveillance in Barrett's Esophagus

This study is being done to see how biomarkers (abnormalities in molecules of cells ) present in their Barrett's esophagus agree with results from surveillance biopsies; and to compare three different brush devices used to collect cells to see which of these 3 brush devices obtains a higher number of cells.

Completed

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Key information

Conditions

Barrett Esophagus Adenocarcinoma Carcinoma Deglutition Disorders Digestive System Diseases Esophageal Diseases Esophageal Motility Disorders Gastroesophageal Reflux Gastrointestinal Diseases Neoplasms Neoplasms by Histologic Type Neoplasms, Glandular and Epithelial Precancerous Conditions

Age range

18 year–90 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Mayo Clinic

Rochester, Minnesota, United States

About this study

During an endoscopy done for clinical surveillance of your Barrett's Esophagus participants are randomized to one of three brush devices by random chance like a flip of a coin. This is being done to see if one collects more cells than the others. A soft brush will be used to collect cells from the lining of the esophagus, this is known as brush cytology. With the endoscope positioned in your esophagus, samples (biopsies) of lining of the esophagus will then be taken to determine the nature of the Barrett's mucosa in the same manner as for any patient undergoing routine surveillance endoscopy for Barrett's esophagus. A part of the specimen will be used to store tissue samples that can later be used.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Patient age greater than 18 years of age
Prior histological demonstration of Barretts Esophagus that is endoscopically visible with no dysplasia
Low grade, high grade dysplasia or early esophageal cancer

Exclusion criteria

None

Sponsors and collaborators

Lead sponsor

Mayo Clinic

Other

Collaborators

National Institutes of Health (NIH)

Registry information

Important dates

Study start: 2007
Primary completion: 2009
Study completion: 2009
First posted: Aug 7, 2009
Registry last updated: Sep 16, 2009

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed