Novel Imaging Biomarkers for Mechanical Complications in Acute Myocardial Infarction

Hemorrhagic Myocardial infarctions are at high risk for mechanical complications including cardiac rupture. Prediction of vulnerable myocardial segments is an important step for the stratification of hemorrhagic MI patients. Wall motion index ratio is an important parameter to determine regions of high vulnerability within the 17-segment LV model of hemorrhagic MI.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Acute Myocardial Infarction Cardiomyopathies Cardiovascular Diseases Heart Diseases Heart Rupture Heart Rupture, Post-Infarction Hemorrhagic Myocardial Infarction Myocardial Hemorrhage Myocardial Ischemia Myocardial Reperfusion Injury Myocardial Rupture (Post Infarct) Myocardial Stunning Pathologic Processes Pathological Conditions, Signs and Symptoms Postoperative Complications Reperfusion Injury Signs and Symptoms Vascular Diseases

Age range

18 year–79 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Krannert Cardiovascular Research Center, Indiana University School of Medicine

Indianapolis, Indiana, 46202, United States

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Index STEMI
Primary PCI
Able to complete Cardiac MR - STRAIN Protocol

Exclusion criteria

Contraindication to CMR (Contrast Hypersensitivity, Metallic Implants, Abnormal Rhythms, breathing difficulties)

Treatment and study plan

Primary outcomes

Wall Strain Index for Potential Detection of Intramyocardial Hemorrhage

Time frame: 48 hours Post-PCI

Difference in Wall Strain Index values between patients with intramyocardial hemorrhage and those without, confirmed by cardiac MRI.
Wall Strain Index in Detecting the Severity of Intramyocardial Hemorrhage

Time frame: 48 hours Post-PCI

Relationship between initial Wall Strain Index measurements and the volume of intramyocardial hemorrhage quantified by cardiac MRI
Wall Strain Index Ratio in Identification of Vulnerable LV Segments for Cardiac Rupture

Time frame: 48 hours Post-PCI

Wall Strain Index Ratio for circumferential and longitudinal strain in identifying vulnerable hemorrhagic left ventricular segments at risk for rupture

Sponsors and collaborators

Lead sponsor

Rohan Dharmakumar

Other

Registry information

Official study title

WSI Ratio as a Biomarker for Mechanical Complication of Hemorrhagic MI

Acronym: MIRON-RUPTURE

Important dates

Study start: 2022
Primary completion: 2024
Study completion: 2024
First posted: Jun 10, 2024
Registry last updated: Jan 14, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed