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Completed

NCT Number: NCT04074278

Novel Equations for Estimating Lean Body Mass in Patients With Chronic Kidney Disease

Simplified methods to estimate lean body mass (LBM), an important nutritional measure representing muscle mass and somatic protein, are lacking in non-dialyzed patients with chronic kidney disease (CKD).

Objective: We developed and tested a reliable equations for estimation of LBM in daily clinical practice.

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Key information

Conditions

Lean Body Mass Chronic Disease Chronic Kidney Diseases Disease Attributes Female Urogenital Diseases Female Urogenital Diseases and Pregnancy Complications Kidney Diseases Male Urogenital Diseases Pathologic Processes Pathological Conditions, Signs and Symptoms Renal Insufficiency Renal Insufficiency, Chronic Urogenital Diseases Urologic Diseases

Age range

18 year–80 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Renal Division and Institute of Nephrology, Peking University First Hospital

Beijing, Beijing Municipality, 100034, China

About this study

Two cross-sectional data sets were derived from outpatients with CKD stage 3-5 in Peking University First Hospital.Two equations for estimating LBM based on midarm muscle circumference (MAMC) or hand grip strength (HGS)were developed and validated in CKD patients with dual-energy x-ray absorptiometry (DEXA) as referenced gold method. Demographic data, comorbidity, and other clinical variables were also recorded.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • non-dialyzed patients with CKD stage 3-5
  • clinical stable
  • a willingness to be examined with all measurements being taken simultaneously.

Exclusion criteria

  • systemic infections, acute cardiovascular events, operations, trauma, active hepatitis or tumor
  • severe edema within one month prior to the study
  • chronic infections, connective tissue disease, hyper- or hypothyroidism, amputations or pregnancy,
  • taking immunosuppressive agents and anti-inflammatory medication chronically

Treatment and study plan

Primary outcomes

  1. LBM_DEXA

    Time frame: between March 1st, 2014 and December 1st, 2015

    lean body mass measured by dual-energy x-ray absorptiometry (DEXA)

Sponsors and collaborators

Lead sponsor

Peking University First Hospital

Other

Registry information

Important dates

Study start
2013
Primary completion
2015
Study completion
2015
First posted
Aug 30, 2019
Registry last updated
Sep 10, 2019

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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