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NCT Number: NCT05657847

Novel Complex Radiodiagnostics of Peripherial Arthropathies

Chronic peripherial arthritides are common diseases with soaring public health consequences. Our goal is to assess the role of photon-counting detector computed tomography in the diagnostics of peripherial arthropathies.

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Key information

Conditions

Arthritis, Rheumatoid Arthritis Arthritis, Psoriatic Autoimmune Diseases Bone Diseases Connective Tissue Diseases Crystal Arthropathies Immune System Diseases Joint Diseases Musculoskeletal Diseases Psoriasis Rheumatic Diseases Skin Diseases Skin Diseases, Papulosquamous Skin and Connective Tissue Diseases Spinal Diseases Spondylarthritis Spondylarthropathies Spondylitis

Age range

18 year–100 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Buda Hospital of the Hospitaller Order of Saint John of God, Budapest, Hungary

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About this study

Background:

Chronic peripherial arthritides include immune-mediated (rheumatoid arthritis, psoriatic arthritis) and crystal deposition diseases (gout, pseudogout, hydroxiapatite-deposition disease).

Conventional radiographs are utilized to screen arthritis-associated deformities, bone erosions and joint space narrowing. MRI is able to detect bone marrow edema, synovitis and the swelling of soft tissues. Sonography can also detect synovitis and soft tissue involvement but does not provide information about bone marrow edema and poorly assess erosions. Photon-counting detector computed tomography (PCD-CT) is a novel type of CT device which provides many advantages like improved signal-to-noise ratio, intrinsic spectral information, lower radiation exposure, and better spatial resolution. PCD-CT is a type of X-ray computed tomography in which X-rays are detected using a photon-counting detector. These detectors are able to directly transform X-ray photons into electrical signals. Compared to previous generation scintillation detectors, photon-counting detectors have several advantages: being able to count the charges created by individual x-ray photons and measuring their energy level also providing multi- energy spectral sensitivity. 0.2 mm slice thickness potentiates the detection of bone erosionss. Collagen-rich structures like cartilage, ligaments, and tendons are easier to identify on PCD-CT images. Bone marrow edema can be visualized with virtual non- calcium reconstruction. PCD-CT could both detect and differentiate cristal deposits.

Aims: To assess the possible role of PCD-CT technique in the diagnostics of peripherial arthropathies.To compare the role of PCD-CT in the detection of arthritis-related pathologies with other imaging modalities like MRI and conventional radiography.

Who can participate

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Rheumatoid arthritis (EULAR/ACR Criteria) / Psoriatic arthritis (CASPAR Criteria)/ Crystal arthropathies
  • signed informed consent

Exclusion criteria

  • age: <18 years, > 100 years
  • pregnant
  • breastfeeding

Treatment and study plan

Photon-counting detector-CT

Device

CT scan

Primary outcomes

  1. Bone erosions

    Time frame: From baseline to at least 2 years

    To assess the detection of arthritis-related bone erosions with different imaging techniques, including PCD-CT.

  2. Bone marrow edema and periarticular soft tissue involvement

    Time frame: From baseline to at least 2 years

    To assess the detection of arthritis-related bone marrow edema and periarticular soft tissue with different imaging techniques, including PCD-CT.

  3. Crystal deposit characterization

    Time frame: From baseline to at least 2 years

    To detect the different crystal deposits with PCD-CT.

Secondary outcomes

  1. To evaluate the performance of PCD-CT in the detection of active arthritis-related imaging findings and structural damages.

    Time frame: From baseline to at least 3 years

    To compare the performance of PCD-CT with different modalities in the diagnostics of peripherial arthropathies.

Sponsors and collaborators

Lead sponsor

Semmelweis University

Other

Collaborators

  • Buda Hospital of the Hospitaller Order of Saint John of God
  • National Institute of Rheumatology and Physiotherapy, Hungary

Registry information

Important dates

Study start
2022
Primary completion
2027
Study completion
2027
First posted
Dec 20, 2022
Registry last updated
Dec 20, 2022

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

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This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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