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Completed

NCT Number: NCT02418416

Novel Approach With Double Agent Artificial Oocyte Activation for Repeated Fertilization Failure Due to Combined Sperm and Oocyte Factor

Novel approach for Oocyte fertilization failure for difficult cases not respond to traditional methods of assisted reproduction as intracytoplasmic sperm injection.

Completed

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Key information

Conditions

Infertility Genital Diseases Urogenital Diseases

Age range

18 year–44 year

Sex eligibility

Female

Study type

Interventional

Phase

Not applicable

Primary location

Al Barka fertility center, Bahrain

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About this study

In some cases undergoes assisted reproduction technique specially Intracytoplasmic sperm injection, in subgroup of patient they fail to fertilize or poorly fertilized, some authors recommend chemical activation for those group of patient with Ca ionophore but still with Ca ionophore there are some cases with total fertilization failure or low fertilization specially in those patient with 2 separate factors like teratozoospermia with poor quality Oocytes so the investigators decided to test the effect of double activation methods by using tow agents proven with life birth rate Ca ionophore and strontium chloride.

We Do intracytoplasmic sperm injection and immediately activate oocyte with Ca Ionophore followed by strontium chloride activation and monitoring the embryogenesis until the blastocyst formation and pregnancy outcome in multicenter assessment.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • poor sperm
  • poor quality Oocytes
  • previous failed fertilization
  • previous poor embryogenesis

Exclusion criteria

  • normal patient
  • previous successful outcome

Treatment and study plan

Oocyte double chemical activation

Other

Oocyte double chemical activation

Primary outcomes

  1. Clinical Pregnancy rate ( % )

    Time frame: 3 months

    To predict percentage of pregnant women from those will undergo Embryo transfer

Secondary outcomes

  1. Blastocyst rate ( % )

    Time frame: 3 months

    Number of embryos will reach blastocyst stage at day 5 post Intracytoplasmic sperm injection

Sponsors and collaborators

Lead sponsor

Ibn Sina Hospital

Other Gov

Collaborators

  • Al Baraka Fertility Hospital
  • Banon IVF Center Assiut, Egypt

Registry information

Official study title

Calcium Ionophore Together With Strontium Chloride Would Likely Have a Positive But Non-traumatic Impact on Human Embryo Development

Acronym: CISC

Important dates

Study start
2015
Primary completion
2016
Study completion
2016
First posted
Apr 16, 2015
Registry last updated
Sep 27, 2018

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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