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Completed

NCT Number: NCT07745153

Novel Abdominal Compression Positioning Technique for Respiratory Motion Management in Liver Tumors

1. Research Background The background of this study centers on stereotactic body radiation therapy (SBRT), an advanced form of radiotherapy that is short in duration, highly effective, and easy for patients to comply with. However, even small breathing movements can reduce its precision. Abdominal compression devices have been proven to reduce respiratory motion and are now widely used in clinical practice. This study aims to determine whether a novel abdominal compression positioning technique can control tumor motion as effectively as current abdominal compression devices, whether it works better than traditional thermoplastic masks, and whether it can offer meaningful benefits to patients undergoing radiotherapy. These questions remain to be explored. 2. Study Objectives The purpose of this study is to investigate how different immobilization devices affect the respiratory motion of liver tumors, in order to better assist with target delineation and the delivery of stereotactic body radiation therapy.

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Key information

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Department of Radiation Oncology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, People's Republic of China

Guangzhou, Guangdong, 510515, China

About this study

This study is a single-center, ambidirectional observational study.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Voluntarily signed informed consent.

Age ≥ 18 years.

Patients who require radiotherapy for liver cancer, as determined by the treating physician.

Life expectancy > 3 months.

Exclusion criteria

  • Discontinuation of radiotherapy or failure to complete the radiotherapy plan as prescribed.

Presence of serious complications or comorbidities that may affect safety.

Treatment and study plan

Primary outcomes

  1. Tumor respiratory motion

    Time frame: Within 1 week after completion of radiotherapy

    Tumor respiratory motion amplitude

  2. Liver respiratory motion

    Time frame: Within 1 week after completion of radiotherapy

    Liver respiratory motion amplitude

Secondary outcomes

  1. Local control rates

    Time frame: Within one year after the completion of radiotherapy

    Status of local tumor control

Sponsors and collaborators

Lead sponsor

Southern Medical University, China

Other

Registry information

Important dates

Study start
2025
Primary completion
2026
Study completion
2026
First posted
Aug 4, 2026
Registry last updated
Aug 4, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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