Normobaric Hypoxic Training and Multiple Sclerosis

To study the effects of normobaric hypoxic training on cardiorespiratory fitness, resting, postprandial and exercise activity energy expenditure, immunoregulatory functions and serum erythropoietin levels in relapsing-remitting multiple sclerosis patients.

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Key information

Conditions

Multiple Sclerosis Autoimmune Diseases Autoimmune Diseases of the Nervous System Behavior Demyelinating Autoimmune Diseases, CNS Demyelinating Diseases Immune System Diseases Motor Activity Nervous System Diseases

Age range

20 year–60 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Experimental & Clinical Research Center

Berlin, 13125, Germany

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

stable immunomodulatory therapy
expanded disability status scale score < 4.5
body mass index 18.5 - 29.9 kg/m2

Exclusion criteria

clinically relevant heart, lung, liver, and kidney diseases

Treatment and study plan

Hypoxic training

Other

Hypoxic training 3 times per week four four weeks

Normoxic training

Other

Normoxic training 3 times per week four four weeks

Primary outcomes

Activity energy expenditure measured by indirect calorimetry (respiratory chamber)

Time frame: Change from baseline at 4 weeks

Sponsors and collaborators

Lead sponsor

Charite University, Berlin, Germany

Other

Registry information

Official study title

Cardiorespiratory, Metabolic and Immunoregulatory Response to Hypoxia in Multiple Sclerosis Patients: A Pilot Study

Acronym: MS_EPOXI

Important dates

Study start: 2015
Primary completion: 2017
Study completion: 2018
First posted: Jul 28, 2015
Registry last updated: Jul 11, 2022

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed