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OpenTrials
Completed

NCT Number: NCT04332406

Normal Ventilatory and Perfusion Pulmonary Function in TEMP

Ventilation - perfusion SPECT is attractive for lung function assessement. Unfortunately, it is very difficult to delineate normal to abnormal areas because of physiological uptake heterogeneity.

In that context, it would be of interest to build statistical maps from registrered normal studies and propose a new methodology for normal SPECT delineation

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Key information

Conditions

Patents With Normal VQ/SPECT

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Médecine nucléaire - Hôpital Morvan (CHRU de Brest)

Brest, 29609, France

About this study

Patients with normal VQ SPECT-CT will be analysed. After a image proccesing workflow including rigid registration, non rigid registration and normalization, a voxelized mean and standard deviation map will be created. Those maps will be analyzed in regards of physiology and litterature.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • normal perfusion and ventilation scans, and no parenchyma or pleural abnormality on low dose CT
  • confirmation by a second senior physician

Exclusion criteria

Patients with history of pulmonary disease:

  • chronic obstruction pulmonary disease,
  • previous pulmonary embolism,
  • surgery of the lungs
  • radiotherapy of the lungs

Treatment and study plan

Primary outcomes

  1. Posterior to Anterior and Inferior to Superior uptake relative difference on parametric mean registered SPECT map versus non registered SPECT

    Time frame: through study completion, an average of 3 months

    parametric mean and standard deviation maps are build from elastic registration of normal lung V/Q SPECT-CT. A ROI based quantitative regional uptake comparison is performed to verify the influence of elastic registration on radiotracer distribution

Sponsors and collaborators

Lead sponsor

University Hospital, Brest

Other

Registry information

Official study title

Normal Ventilatory and Perfusion Pulmonary Function in TEMP: Generation of 3D Statistical Maps From Normal Examinations

Acronym: 3DSPECSTAT

Important dates

Study start
2019
Primary completion
2019
Study completion
2019
First posted
Apr 2, 2020
Registry last updated
Apr 2, 2020

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.