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NCT Number: NCT05628974

Normal Donor Blood Draws for Platelet Studies and Biomarker Evaluation (ND-PLT)

This is a single-center study at the Cleveland Clinic Main Campus designed to study biomarkers in healthy individuals to identify novel mechanisms of platelet activation and how platelets drive vascular inflammation and thrombosis in diseases.

Recruiting

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Key information

Conditions

Healthy

Age range

18 year–65 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Cleveland Clinic

Cleveland, Ohio, 44195, United States

Location status: Recruiting

Location contact

Morayma Reyes Gil, MD

SUB_INVESTIGATOR

Rohan Bhandari, MD

SUB_INVESTIGATOR

Scott Cameron, MD, PhD

CONTACT

[email protected]

216-444-1680

Teresa Wu, MD

SUB_INVESTIGATOR

About this study

Our past studies have discovered novel platelet activation pathways that may be targets of therapeutic development. We have also defined an important role for a shift in platelet phenotype in vascular disease. Our studies use both in vivo animal models and validation using human platelets from isolated blood. Platelets from healthy individuals may be compared to patients with vascular diseases in the IRB approved protocol "Vascular Lab Resource" (IRB #19-1451) study which is actively recruiting patients at the Cleveland Clinic Main Campus and studies patients with vascular diseases.

Who can participate

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Adults aged 18 to 65 years old
  • Healthy Male & Female voluntary participants

Exclusion criteria

  • Individuals who have taken anticoagulant or antiplatelet medications in past 10 days
  • Individuals with hematopoetic diseases

Treatment and study plan

Primary outcomes

  1. To collect blood samples

    Time frame: 10 years

    To establish a biorepository for normal healthy cohort of subjects

Study contacts

Contact information is provided by the study sponsor or research team.

Scott Cameron, MD, PhD

CONTACT

[email protected]

216-444-1680

Sponsors and collaborators

Lead sponsor

The Cleveland Clinic

Other

Collaborators

  • National Heart, Lung, and Blood Institute (NHLBI)

Registry information

Acronym: ND-PLT

Important dates

Study start
2020
Primary completion
2030
Study completion
2031
First posted
Nov 29, 2022
Registry last updated
Dec 16, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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