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OpenTrials
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NCT Number: NCT03027869

Normal Brain Imaging Database for Brain Disorder Studies

Healthy volunteers will be recruited. All subjects will be tested a battery of neuropsychological tests, then undergo fluorodeoxyglucose-positron emission tomography (PET) and magnetic resonance imaging (MRI). During the PET and MRI, they will be stimulated with transcranial direct current stimulation (tDCS) for 15 minutes. A third of subjects will receive real tDCS on the left prefrontal cortex, a third on the right prefrontal cortex, and the other third will receive sham tDCS.

Active, Not Recruiting

This study is active but is not currently recruiting participants.

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Key information

Conditions

Healthy

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

University of Manitoba

Winnipeg, Manitoba, R3E 0J9, Canada

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • N/A

Exclusion criteria

  • History of any neurological or psychiatric diseases;
  • Abnormal MRI;
  • metal implants or a cardiac pacemaker;
  • Pregnant or breastfeeding women (female subjects of child bearing potential will be screened for pregnancy before MRI imaging).
  • severe hypertension.
  • cardiovascular disease.
  • Family history of epilepsy.

Treatment and study plan

Transcranial Direct Current Stimulation

Device

15 minute anodal stimulation 1.5mA

Primary outcomes

  1. functional connectivity

    Time frame: immediate (less than 30 minutes)

    The functional connectivity of the right caudate nucleus will be estimated using graph theory analysis technique of resting-state fMRI.

Secondary outcomes

  1. Stroop task performance

    Time frame: immediate (less than 60 minutes)

    the executive function that is thought to involve the caudate nucleus will be examined

Sponsors and collaborators

Lead sponsor

University of Manitoba

Other

Registry information

Acronym: Normal_tDCS

Important dates

Study start
2017
Primary completion
2020
Study completion
2025
First posted
Jan 23, 2017
Registry last updated
Apr 3, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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