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Completed

NCT Number: NCT00763906

Norepinephrine Weaning in Septic Patients

The weaning rate of vasopressors drugs is usually chosen empirically by the clinician in critically patients. The investigators applied fuzzy logic principles to modify intravenous norepinephrine infusion rates during norepinephrine infusion in septic patients in order to reduce the duration of shock. The investigators goal was to reduce the duration of poorly controlled hemodynamic status.

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Key information

Conditions

Septic Shock Infections Inflammation Pathologic Processes Pathological Conditions, Signs and Symptoms Sepsis Shock Shock, Septic Systemic Inflammatory Response Syndrome

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 4

Primary location

Réanimation

Bobigny, Seine-Saint-Denis, 93000, France

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Septic shock

Exclusion criteria

  • Less than 18 years
  • Pregnancy
  • Weight above 135 kg
  • Requirement for continuous epinephrine infusion
  • Severe head injury, stroke, a comatose state following cardiac arrest

Treatment and study plan

norepinephrine infused at the clinician's discretion

Device

norepinephrine infused under computerized fuzzy logic control

Device

Primary outcomes

  1. Time to shock resolution defined as cessation of vasopressor support

Secondary outcomes

  1. 28 days survival, total amount of norepinephrine infused, duration of mechanical ventilation, and length of stay in the ICU

Sponsors and collaborators

Lead sponsor

Association pour le Développement de la Recherche et de l'Enseignement en Médecine d'Urgence

Other

Registry information

Official study title

Continuous Administration of Norepinephrine Assisted by Fuzzy Logic Assisted Control in Septic Shock Patients

Acronym: CATECHOFLOU

Important dates

Study start
2004
Primary completion
2006
Study completion
2007
First posted
Oct 1, 2008
Registry last updated
Oct 1, 2008

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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