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OpenTrials
Completed

NCT Number: NCT04710836

NoRCoRP Assessment Clinic

The main overarching aim of this study is to build a research clinic, as part of the NoRCoRP platform covering Nottingham and Nottinghamshire to facilitate learning and research in the whole population of patients who have had COVID-19.

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Key information

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Nottingham City Hospital

Nottingham, NG5 1PB, United Kingdom

About this study

The severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2 / COVID-19) pandemic, has affected over 13 million people, and caused significant worldwide mortality and morbidity. Frequent long-term respiratory complications include persistent breathlessness and fatigue, with potential for ongoing organising pneumonia and new pulmonary fibrosis as well as thromboembolic disease. Additional features seen in at least some patients post hospital include impaired musculoskeletal function, impaired renal function, neurological impairment, cardiac dysfunction and significant psychiatric morbidity.

The majority of patients with COVID-19 were not admitted to hospital, and the longer-term consequences of infection with SARS-CoV-2 in this much larger patient group are unknown. Whilst many patients had relatively mild disease and made a good recovery, a significant number have been left with symptoms similar to those who were admitted to hospital.

In setting up a post COVID-19 respiratory review clinic, we expect to generate new findings, support studies that have already been submitted for funding, to provide a focus for further grant funding, and to provide an infrastructure to support new clinical trials. We also expect the insights gained from research using this platform to be of value for service planning in the region and beyond. We will prioritise patients who were not admitted to hospital but who have been left with significant morbidity by establishing this new General Practitioner (GP) referral research clinic.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Adults (≥18 years) referred into the post COVID-19 respiratory outpatient clinic from primary care, following a swab, imaging or strong clinical diagnosis of COVID-19
  • Adults discharged from hospital with a clinical diagnosis of COVID-19 (who are not included in the PHOSP-COVID study)

Exclusion criteria

  • Children (<18 years) referred into the post COVID-19 respiratory outpatient clinic. This clinic is only open to adults and referrals for children will not be accepted
  • Adults discharged from hospital with a clinical diagnosis of COVID-19 and have been included in the PHOSP-COVID study
  • Patients unable to provide informed consent by themselves

Treatment and study plan

Primary outcomes

  1. Number of participants with symptoms at presentation to the research clinic

    Time frame: September 2020 - August 2024

    Patient reported symptoms

  2. Short Physical Performance Battery

    Time frame: September 2020 - August 2024

    Assessment of functional capacity

  3. Quadricep muscle strength

    Time frame: September 2020 - August 2024

    Assessment of functional capacity using a handheld dynamometer

  4. Chalder's Fatigue Score

    Time frame: September 2020 - August 2024

    Assessment of fatigue using the Chalder 11-item fatigue questionnaire

  5. Number of participants with rehabilitation needs at presentation to clinic

    Time frame: September 2020 - August 2024

    Rehabilitation needs based on clinical assessment by a multidisciplinary team (musculoskeletal, cognitive and cardiopulmonary)

  6. EQ-5D-5L

    Time frame: September 2020 - August 2024

    Assessment of generic health status using the EQ-5D-5L questionnaire

  7. Montreal Cognitive Assessment

    Time frame: September 2020 - August 2024

    Assessment of cognitive state using the MoCA questionnaire

Secondary outcomes

  1. Anxiety and Depression

    Time frame: September 2020 - August 2024

    Derived by completion of the Hospital Anxiety and Depression Scale (HADS) questionnaire

  2. Pittsburgh Sleep Quality Index

    Time frame: September 2020 - August 2024

    Assessment of sleep quality using the PSQI questionnaire

  3. Healthcare service needs following COVID-19 diagnosis

    Time frame: September 2020 - August 2032

    Monitoring of NHS records for incidence of re-presentation to primary or secondary care related to COVID-19 complications and survival.

  4. Biological markers of recovery from COVID-19

    Time frame: September 2020 - August 2032

    Assessment of blood taken for clinical purposes (where available) including renal function, liver function, full blood count, HbA1C, Brain natriuretic peptide, vitamin D, thyroid function, C-reactive protein (CRP), Creatine kinase for markers of COVID-19 recovery. Batched inflammatory and metabolic markers as well as whole blood DNA will also be assessed from stored samples.

  5. Fried Frailty Index

    Time frame: September 2020 - August 2024

    Frailty assessment covering: shrinking, exhaustion, physical activity, slowness and weakness domains.

  6. Body composition

    Time frame: September 2020 - August 2024

    Body composition derived from bioelectrical impedance analysis to determine: body mass index, fat free mass index, fat free mass (kg), fat mass (kg).

Sponsors and collaborators

Lead sponsor

Nottingham University Hospitals NHS Trust

Other

Registry information

Official study title

The Nottingham Recovery From COVID-19 Research Platform Assessment Clinic

Acronym: NoRCoRP

Important dates

Study start
2020
Primary completion
2024
Study completion
2024
First posted
Jan 15, 2021
Registry last updated
Jun 29, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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