Skip to main content
OpenTrials
Recruiting

NCT Number: NCT07350629

Noninvasive Real-Time Arterial Waveform Monitoring for Cardiovascular Disease Assessment

The goal of this observational study is to learn whether noninvasive real-time arterial waveform monitoring can be used to assess cardiovascular diseases in adults. The main question it aims to answer is:

Can photoacoustic imaging accurately capture arterial waveforms from patients' fingers? Can features extracted from the arterial waveforms reflect the type and severity of cardiovascular diseases? Participants will be asked to place their fingers into the imaging device, where their finger arterial pulse information will be noninvasively recorded.

Recruiting

Interested in participating?

Request Info

Key information

Conditions

Aortic Regurgitation Disease Aortic Stenosis Disease Healthy Subjects

Age range

18 year–80 year

Sex eligibility

All sexes

Study type

Observational

Primary location

the First Affiliated Hospital of University of Science and Technology of China

Hefei, Anhui, 230026, China

Location status: Recruiting

Location contact

Haoxin Gu

CONTACT

[email protected]

86-18810938389

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age 18-80 years
  • Able to provide informed consent
  • For AR group: clinically diagnosed aortic regurgitation
  • For AS group: clinically diagnosed aortic stenosis
  • For healthy controls: no history of cardiovascular disease
  • Able to undergo finger arterial waveform measurement

Exclusion criteria

  • History of recent cardiac surgery or intervention (<6 months)
  • Hand disorders affecting finger mobility (e.g., arthritis)
  • Pregnant or breastfeeding women
  • Participation in other studies affecting arterial waveform
  • Unable to understand or comply with study procedures

Treatment and study plan

Primary outcomes

  1. Evaluation of the state of aortic regurgitation and aortic stenosis by photoacoustic tomography

    Time frame: At enrollment (single time point)

    To determine the feasibility of using photoacoustic tomography to differentiate aortic regurgitation and aortic stenosis based on arterial waveform measurements.

Secondary outcomes

  1. Rise time of photoaocustic arterial waveform

    Time frame: At enrollment (single time point)

    To determine the systolic upstroke rise time of arterial waveforms using photoacoustic tomography

  2. Decay time of photoaocustic arterial waveform

    Time frame: At enrollment (single time point)

    To determine the diastolic decay time of arterial waveforms using photoacoustic tomography

  3. Dicrotic notch time of photoaocustic arterial waveform

    Time frame: At enrollment (single time point)

    To determine the dicrotic notch time of arterial waveforms using photoacoustic tomography

Sponsors and collaborators

Lead sponsor

Anhui Provincial Cancer Hospital

Other

Registry information

Official study title

A Study on Noninvasive Real-Time Arterial Pressure Waveform Analysis for the Detection and Evaluation of Cardiovascular Diseases

Important dates

Study start
2025
Primary completion
2026
Study completion
2026
First posted
Jan 20, 2026
Registry last updated
Jan 20, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.