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Completed

NCT Number: NCT04540328

Non-surgical Peridontal Treatment on Cardiovascular Risk Markers

The study evaluates the influence of non-surgical mechanical periodontal treatment in patients with severe chronic periodontitis on inflammatory markers related to risk for cardiovascular diseases

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Key information

Conditions

Cardiovascular Risk Markers Chronic Disease Chronic Periodontitis Disease Attributes Mouth Diseases Pathologic Processes Pathological Conditions, Signs and Symptoms Periodontal Diseases Periodontitis Stomatognathic Diseases

Age range

30 year–54 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

About this study

A total of 80 non-smokers with systemically healthy, including 40 patients with severe chronic periodontitis and 40 periodontally health subjects were included into the present study. The probing depth, clinical attachment level, plaque index, gingival index and blood samples were collected at baseline and at the 3rd months after treatment and the serum levels of asymmetric dimethylarginine (ADMA), endothelial nitric oxide synthase (eNOS), homocysteine (Hcy), monocyte chemoattractant protein-1 (MCP-1) were determined with enzyme-linked immunosorbent assay (ELISA).

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Clinical diagnosis of severe chronic periodontitis

Clinical diagnosis of periodontal health

Exclusion criteria

Systemic diseases such as diabetes, cardiovascular disease

Periodontal treatment within the previous year

Drugs such as systemic steroids, non-steroidal anti-inflammatory drugs, immunosuppressants, hormone drugs, contraceptives, anticoagulants, cholesterol regulating drugs, systemic antibiotics, antioxidants within the previous 3 months

Pregnant or lactating

Consumed alcohol

Smoker

Treatment and study plan

Non-surgical periodontal treatment

Other

Primary outcomes

  1. Asymmetric dimethylarginine (ADMA)

    Time frame: At the 3rd months after non-surgical periodontal treatment

    Serum Concentration (pg/mL)

  2. Endothelial nitric oxide synthase (eNOS)

    Time frame: At the 3rd months after non-surgical periodontal treatment

    Serum Concentration (pg/mL)

  3. Homocysteine (Hcy)

    Time frame: At the 3rd months after non-surgical periodontal treatment

    Serum Concentration (nmol/mL)

  4. Monocyte chemoattractant protein-1 (MCP-1)

    Time frame: At the 3rd months after non-surgical periodontal treatment

    Serum Concentration (ng/mL)

Secondary outcomes

  1. Clinical periodontal parameter

    Time frame: At the 3rd months after non-surgical periodontal treatment

    Clinical attachment level (mm)

Sponsors and collaborators

Lead sponsor

Kırıkkale University

Other

Registry information

Official study title

Effect of Non-surgical Peridontal Treatment on Cardiovascular Risk Markers in Patients With Severe Chronic Periodontitis

Important dates

Study start
2015
Primary completion
2016
Study completion
2017
First posted
Sep 7, 2020
Registry last updated
Sep 7, 2020

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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